Asthma, Allergy and Immunotherapy

Coordinator : L. Reber

Scientific objectives


Allergies are major public health problems of increasing prevalence. The World Health Organization (WHO) indicates that 50% people will suffer from at least one type of allergy in 2050.

Our research focuses on deciphering the cellular and molecular mechanisms of allergies, in order to identify potential new therapeutic targets. To assess this, we use in vivo models of allergies (allergic asthma, food allergy, anaphylaxis, atopic dermatitis), combined with the use of clinical samples from allergic patients, in collaboration with clinical teams of Toulouse university hospital. We are also specialized in preclinical and clinical development of immunotherapies for allergic diseases.

 

Our projects


Decipher the cellular and molecular mechanisms of allergic shock reactions (anaphylaxis)

Allergic shock, also known as anaphylaxis, is a rapid and systemic allergic reaction which can be fatal. The current paradigm states that in human, anaphylaxis is mostly triggered by allergen-specific IgE antibodies. Upon exposure to an allergen in sensitized patients, such allergen is recognized by IgE bound to their receptor on the surface of mast cells, which lead to the activation of mast cells and the release of histamine responsible for most clinical signs of anaphylaxis. Anaphylaxis represents an emergency situation for the medical staff, which makes the study of the mechanisms of human anaphylaxis very difficult. For this reason, several mouse models of anaphylaxis have been generated and used to gain insight into the mechanisms of this allergic reaction.

Our previous results show that, in mice, two main pathways of anaphylaxis coexist : a “classical” pathway induced by IgE antibodies, mast cells and histamine, and an “alternative” pathway induced by IgG antibodies which can activate myeloid cells, leading to the release of platelet-activating factor (PAF). Our research aims at demonstrating that these classical and alternative pathways also coexist in human anaphylaxis. To do so, we use clinical samples from allergic patients, combined with humanized mouse models which allow us to directly assess the mechanisms of anaphylaxis induced by human antibodies.

Development of new immunotherapies for allergic diseases

Allergies are major public health problems for which there is, in most cases, no efficient long-term therapy. The main goal of our research is to develop new immunotherapies which could induce efficient and long-term protection against allergies. We focus on both passive (therapeutic monoclonal antibodies) and active immunotherapies (allergen-specific immunotherapies and vaccine approaches). We use in vivo models of major allergies (asthma, food allergy, anaphylaxis and atopic dermatitis) to test the efficiency of these passive and active immunotherapeutic approaches. In addition, some of the validated immunotherapies are used by the clinicians of our team to treat allergic patients.

Clinical research in severe asthma

The vision of asthma has dramatically changed over the past ten years. This entity is not consider a single disease but encompasses a heterogeneous group of diseases. Asthma in obese subjects is characterized by more severe symptoms and is more difficult to control in clinical practice. An interregional Hospital Clinical Research Project (PHRC) has recently been accepted to study the effect of intragastric balloons in uncontrolled obese asthmatics. Our team is widely involved in academic and industrial clinical trials in severe asthma. We share the coordination, together with the Nantes team, of a network called CRISALIS (Severe Asthma Clinical Research Initiative: a lever for innovation and science) supported by F-CRIN (French Network for Clinical Research Infrastructure) (INSERM). Clinical teams from 11 teaching hospitals work altogether in this network which greatly improve clinical research in severe asthma in France. We are particularly responsible for the group on the role of obesity and other comorbidities in severe asthma.

Other informations


Publications

2020

Guibert, N; Guilleminault, L; Lepage, B; Heluain, V; Fumat, R; Dupuis, M; Faviez, G; Plat, G; Hermant, C; Didier, A

Bronchial thermoplasty in patients with dynamic hyperinflation: Results from the proof-of-concept HEAT trial Article de journal

Eur Respir J., 2020.

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Dupin, C; Belhadi, D; Guilleminault, L; Gamez, A S; Berger, P; De Blay, F; Bonniaud, P; Leroyer, C; Mahay, G; Girodet, P O; Raherison, C; Fry, S; Le Bourdellès, G; Proust, A; Rosencher, L; Garcia, G; Bourdin, A; Chenivesse, C; Didier, A; Couffignal, C; Taillé, C

Effectiveness and safety of dupilumab for the treatment of severe asthma in a real-life French multi-centre adult cohort. Article de journal

Clin Exp Allergy, 50 (7), p. 789-798, 2020.

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Descazeaux, M; Brouquières, D; Didier, A; Lescouzères, M; Napoléon, M F; Escamilla, R; Guilleminault, L

Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough. Article de journal

Lung, 198 (3), p. 441-448, 2020.

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Goyard, S; Balbino, B; Chinthrajah, R S; Lyu, S C; Janin, Y L; Bruhns, P; Poncet, P; Galli, S J; Nadeau, K C; Reber, L L; Rose, T

A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples. Article de journal

Allergy, 2020.

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Balbino, B; Herviou, P; o Godon,; Stackowicz, J; Goff, O R; Iannascoli, B; Sterlin, D; Brûlé, S; Millot, G A; Harris, F M; Voronina, V A; Nadeau, K C; Macdonald, L E; Murphy, A J; Bruhns, P; Reber, L L

The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors. Article de journal

J Clin Invest, 130 (3), p. 1330-1335, 2020.

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Stackowicz, J; Jönsson, F; Reber, L L

Mouse Models and Tools for the in vivo Study of Neutrophils. Article de journal

Frony Immunol, 2020.

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Dardé, X; Mailhol, C; Migueres, I; Didier, A; Guilleminault, L

Overweight and bronchospasm during general anaesthesia: An association with heterogeneous mechanisms. Article de journal

Allergol Int, S1323-8930 (20), 2020.

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Gruzelle, V; C., Mailhol; W., Waters D; L., Guilleminault

Clinical Utility of Rush Venom Immunotherapy: Current Status. Article de journal

J Asthma Allergy, 13 , p. 1-10, 2020.

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2019

Serhan, N; Basso, L; Sibilano, R; Petitfils, C; Meixiong, J; Bonnart, C; Reber, L L; Marichal, T; Starkl, P; Cenac, N; Dong, X; Tsai, M; Galli, S J; Gaudenzio, N

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation Article de journal

Nat Immunol, 20 (11), p. 1435-1443, 2019.

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Wang, Q; Lepus, C M; Raghu, H; Reber, L L; Tsai, M M; Wong, H H; von Kaeppler, E; Lingampalli, N; Bloom, M S; Hu, N; Elliott, E E; Oliviero, F; Punzi, L; Giori, N J; Goodman, S B; Chu, C R; Sokolove, J; Fukuoka, Y; Schwartz, L B; Galli, S J; Robinson, W H

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis. Article de journal

Elife, 2019.

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Piliponsky, A M; Shubin, N J; Lahiri, A K; Truong, P; Clauson, M; Niino, K; Tsuha, A L; Nedospasov, S A; Karasuyama, H; Reber, L L; Tsai, M; Mukai, K; Galli, S J

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice Article de journal

Nat Immunol, 20 (2), p. 129-140, 2019, ISSN: 1529-2916 (Electronic) 1529-2908 (Linking).

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Verduyn, M; Botto, G; Jaubert, J; Lier, C; Flament, T; Guilleminault, L

Serum IgG concentrations in adult patients experiencing virus-induced severe asthma exacerbations Article de journal

J Allergy Clin Immunol Pract, 2019, ISSN: 2213-2201 (Electronic).

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2018

Balbino, B; Conde, E; Marichal, T; Starkl, P; Reber, L L

Approaches to target IgE antibodies in allergic diseases Article de journal

Pharmacol Ther, 191 , p. 50-64, 2018, ISSN: 1879-016X (Electronic) 0163-7258 (Linking).

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Boghanim, T; Murris, M; Lamon, T; Huynh, A; Mazieres, J; Marquette, C H; Didier, A

Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation Article de journal

Lung, 2018, ISSN: 1432-1750 (Electronic) 0341-2040 (Linking).

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Droneau, S; Noel-Savina, E; Plat, G; Murris-Espin, M; Leborgne-Krams, A; Brouchet, L; Dahan, M; Didier, A

Use of Ultrasonography for Lung Transplant Recipients on Postoperative Care Article de journal

J Ultrasound Med, 2018, ISSN: 1550-9613 (Electronic) 0278-4297 (Linking).

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Dupuis, M; Noel-Savina, E; Prevot, G; Tetu, L; Pillard, F; Riviere, D; Didier, A

Determination of Cardiac Output in Pulmonary Hypertension Using Impedance Cardiography Article de journal

Respiration, 96 (6), p. 500-506, 2018, ISSN: 1423-0356 (Electronic) 0025-7931 (Linking).

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Gaudenzio, N; Marichal, T; Galli, S J; Reber, L L

Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity Article de journal

Front Immunol, 9 , p. 1275, 2018, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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Gillis, C M; Reber, L L

[PMN(DTR) mice: a new model to study neutrophils in vivo] Article de journal

Med Sci (Paris), 34 (4), p. 339-343, 2018, ISSN: 1958-5381 (Electronic) 0767-0974 (Linking).

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Gruzelle, V; Ramassamy, M; Bulai Lidiveanu, C; Didier, A; Mailhol, C; Guilleminault, L

Safety of ultra-rush protocols for hymenoptera venom immunotherapy in systemic mastocytosis Article de journal

Allergy, 73 (11), p. 2260-2263, 2018, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Guibert, N; Mhanna, L; Didier, A; Moreno, B; Leyx, P; Plat, G; Mazieres, J; Hermant, C

Integration of 3D printing and additive manufacturing in the interventional pulmonologist's toolbox Article de journal

Respir Med, 134 , p. 139-142, 2018, ISSN: 1532-3064 (Electronic) 0954-6111 (Linking).

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Guilleminault, L; Rolland, Y; Didier, A

[Characteristics of non-pharmacological interventions in the elderly with COPD. Smoking cessation, pulmonary rehabilitation, nutritional management and patient education] Article de journal

Rev Mal Respir, 35 (6), p. 626-641, 2018, ISSN: 1776-2588 (Electronic) 0761-8425 (Linking).

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Hachulla, E; Jais, X; Cinquetti, G; Clerson, P; Rottat, L; Launay, D; Cottin, V; Habib, G; Prevot, G; Chabanne, C; Fois, E; Amoura, Z; Mouthon, L; Le Guern, V; Montani, D; Simonneau, G; Humbert, M; Sobanski, V; Sitbon, O; French Collaborators Recruiting, Members

Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus: Results From the French Pulmonary Hypertension Registry Article de journal

Chest, 153 (1), p. 143-151, 2018, ISSN: 1931-3543 (Electronic) 0012-3692 (Linking).

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Humbert, M; Taille, C; Mala, L; Le Gros, V; Just, J; Molimard, M; investigators , Stellair

Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study Article de journal

Eur Respir J, 51 (5), 2018, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Mailhol, C; Delcourt, N; Apoil, P A; Didier, A; Franchitto, N

Are changes necessary in the medical management of a patient with snakebite regarding the incidence of hypersensitivity reaction to antivenom polyvalent immune fab? Article de journal

Clin Toxicol (Phila), 56 (4), p. 310-311, 2018, ISSN: 1556-9519 (Electronic) 1556-3650 (Linking).

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Secher, T; Guilleminault, L; Reckamp, K; Amanam, I; Plantier, L; Heuze-Vourc'h, N

Therapeutic antibodies: A new era in the treatment of respiratory diseases? Article de journal

Pharmacol Ther, 189 , p. 149-172, 2018, ISSN: 1879-016X (Electronic) 0163-7258 (Linking).

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Seguro, F; Bard, V; Sedkaoui, K; Riche, M; Didier, A; Bouhanick, B

Screening obstructive sleep apnea-hypopnea syndrome in hypertensive patients: a comparative study of the efficiency of the Epworth sleepiness scale Article de journal

BMC Pulm Med, 18 (1), p. 173, 2018, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Stackowicz, J; Balbino, B; Todorova, B; Godon, O; Iannascoli, B; Jonsson, F; Bruhns, P; Reber, L L

Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction Article de journal

Nat Commun, 9 (1), p. 2304, 2018, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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2017

Balbino, B; Sibilano, R; Starkl, P; Marichal, T; Gaudenzio, N; Karasuyama, H; Bruhns, P; Tsai, M; Reber, L L; Galli, S J

Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis Article de journal

J Allergy Clin Immunol, 139 (2), p. 584-596 e10, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Beau, A B; Didier, A; Hurault-Delarue, C; Montastruc, J L; Lacroix, I; Damase-Michel, C

Prescription of asthma medications before and during pregnancy in France: An observational drug study using the EFEMERIS database Article de journal

J Asthma, 54 (3), p. 258-264, 2017, ISSN: 1532-4303 (Electronic) 0277-0903 (Linking).

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Beutier, H; Gillis, C M; Iannascoli, B; Godon, O; England, P; Sibilano, R; Reber, L L; Galli, S J; Cragg, M S; Van Rooijen, N; Mancardi, D A; Bruhns, P; Jonsson, F

IgG subclasses determine pathways of anaphylaxis in mice Article de journal

J Allergy Clin Immunol, 139 (1), p. 269-280 e7, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Casale, T B; Cox, L S; Wahn, U; Golden, D B K; Bons, B; Didier, A

Safety Review of 5-Grass Pollen Tablet from Pooled Data of Clinical Trials Article de journal

J Allergy Clin Immunol Pract, 5 (6), p. 1717-1727 e1, 2017, ISSN: 2213-2201 (Electronic).

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Chavoin, J P; Dahan, M; Savina, E N; Didier, A; Chaput, B

Reply: Correction of Pectus Excavatum by Custom-Made Silicone Implants: Contribution of Computer-Aided Design Reconstruction. A 20-Year Experience and 401 Cases Article de journal

Plast Reconstr Surg, 139 (1), p. 325e-326e, 2017, ISSN: 1529-4242 (Electronic) 0032-1052 (Linking).

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Guibert, N; Didier, A; Moreno, B; Mhanna, L; Brouchet, L; Plat, G; Hermant, C; Mazieres, J

Treatment of Post-transplant Complex Airway Stenosis with a Three-Dimensional, Computer-assisted Customized Airway Stent Article de journal

Am J Respir Crit Care Med, 195 (7), p. e31-e33, 2017, ISSN: 1535-4970 (Electronic) 1073-449X (Linking).

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Guibert, N; Moreno, B; Plat, G; Didier, A; Mazieres, J; Hermant, C

Stenting of Complex Malignant Central-Airway Obstruction Guided by a Three-Dimensional Printed Model Of The Airways Article de journal

Ann Thorac Surg, 103 (4), p. e357-e359, 2017, ISSN: 1552-6259 (Electronic) 0003-4975 (Linking).

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Guilleminault, L; Ouksel, H; Belleguic, C; Le Guen, Y; Germaud, P; Desfleurs, E; Leroyer, C; Magnan, A

Personalised medicine in asthma: from curative to preventive medicine Article de journal

Eur Respir Rev, 26 (143), 2017, ISSN: 1600-0617 (Electronic) 0905-9180 (Linking).

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Guilleminault, L; Viala-Gastan, C

[Blomia tropicalis: A house dust mite in the tropics] Article de journal

Rev Mal Respir, 34 (8), p. 791-801, 2017, ISSN: 1776-2588 (Electronic) 0761-8425 (Linking).

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Guilleminault, L; Williams, E J; Scott, H A; Berthon, B S; Jensen, M; Wood, L G

Diet and Asthma: Is It Time to Adapt Our Message? Article de journal

Nutrients, 9 (11), 2017, ISSN: 2072-6643 (Electronic) 2072-6643 (Linking).

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Joulia, R; Mailhol, C; Valitutti, S; Didier, A; Espinosa, E

Direct monitoring of basophil degranulation by using avidin-based probes Article de journal

J Allergy Clin Immunol, 140 (4), p. 1159-1162 e6, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Morelot-Panzini, C; Adler, D; Aguilaniu, B; Allard, E; Bautin, N; Beaumont, M; Blanc, F X; Chenivesse, C; Dangers, L; Delclaux, C; Demoule, A; Devillier, P; Didier, A; Georges, M; Housset, B; Janssens, J P; Laveneziana, P; Laviolette, L; Muir, J F; Ninot, G; Perez, T; Peiffer, C; Schmidt, M; Similowski, T; Straus, C; Taille, C; Van Den Broecke, S; Roche, N; dyspnoea working group of the Societe de Pneumologie de Langue, Francaise

Breathlessness despite optimal pathophysiological treatment: on the relevance of being chronic Article de journal

Eur Respir J, 50 (3), 2017, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Paganin, F; Mangiapan, G; Proust, A; Prudhomme, A; Attia, J; Marchand-Adam, S; Pellet, F; Milhe, F; Melloni, B; Bernady, A; Raspaud, C; Nocent, C; Berger, P; Guilleminault, L

Lung function parameters in omalizumab responder patients: An interesting tool? Article de journal

Allergy, 72 (12), p. 1953-1961, 2017, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Reber, L L; Gillis, C M; Starkl, P; Jonsson, F; Sibilano, R; Marichal, T; Gaudenzio, N; Berard, M; Rogalla, S; Contag, C H; Bruhns, P; Galli, S J

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide Article de journal

J Exp Med, 214 (5), p. 1249-1258, 2017, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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Reber, L L; Hernandez, J D; Galli, S J

The pathophysiology of anaphylaxis Article de journal

J Allergy Clin Immunol, 140 (2), p. 335-348, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Reber, L L; Sibilano, R; Starkl, P; Roers, A; Grimbaldeston, M A; Tsai, M; Gaudenzio, N; Galli, S J

Imaging protective mast cells in living mice during severe contact hypersensitivity Article de journal

JCI Insight, 2 (9), 2017, ISSN: 2379-3708 (Electronic) 2379-3708 (Linking).

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Reber, L L; Starkl, P; Balbino, B; Sibilano, R; Gaudenzio, N; Rogalla, S; Sensarn, S; Kang, D; Raghu, H; Sokolove, J; Robinson, W H; Contag, C H; Tsai, M; Galli, S J

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice Article de journal

PLoS One, 12 (10), p. e0185704, 2017, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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2016

Bousquet, J; Schunemann, H J; Hellings, P W; Arnavielhe, S; Bachert, C; Bedbrook, A; Bergmann, K C; Bosnic-Anticevich, S; Brozek, J; Calderon, M; Canonica, G W; Casale, T B; Chavannes, N H; Cox, L; Chrystyn, H; Cruz, A A; Dahl, R; De Carlo, G; Demoly, P; Devillier, P; Dray, G; Fletcher, M; Fokkens, W J; Fonseca, J; Gonzalez-Diaz, S N; Grouse, L; Keil, T; Kuna, P; Larenas-Linnemann, D; Lodrup Carlsen, K C; Meltzer, E O; Mullol, J; Muraro, A; Naclerio, R N; Palkonen, S; Papadopoulos, N G; Passalacqua, G; Price, D; Ryan, D; Samolinski, B; Scadding, G K; Sheikh, A; Spertini, F; Valiulis, A; Valovirta, E; Walker, S; Wickman, M; Yorgancioglu, A; Haahtela, T; Zuberbier, T; study , Mask

MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis Article de journal

J Allergy Clin Immunol, 138 (2), p. 367-374 e2, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Cox, L S; Didier, A; Demoly, P; Wahn, U; Pradalier, A; Frew, A J; Devillier, P

Methodological aspects of a meta-analysis of grass pollen allergen sublingual immunotherapy tablets Article de journal

J Allergy Clin Immunol, 138 (1), p. 314-315 e4, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Dupin, C; Marchand-Adam, S; Favelle, O; Costes, R; Gatault, P; Diot, P; Grammatico-Guillon, L; Guilleminault, L

Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation Article de journal

J Clin Immunol, 36 (8), p. 810-817, 2016, ISSN: 1573-2592 (Electronic) 0271-9142 (Linking).

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Flament, T; Marchand-Adam, S; Gatault, P; Dupin, C; Diot, P; Guilleminault, L

What are the characteristics of asthma patients with elevated serum IgG4 levels? Article de journal

Respir Med, 112 , p. 39-44, 2016, ISSN: 1532-3064 (Electronic) 0954-6111 (Linking).

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Gaudenzio, N; Sibilano, R; Marichal, T; Starkl, P; Reber, L L; Cenac, N; McNeil, B D; Dong, X; Hernandez, J D; Sagi-Eisenberg, R; Hammel, I; Roers, A; Valitutti, S; Tsai, M; Espinosa, E; Galli, S J

Different activation signals induce distinct mast cell degranulation strategies Article de journal

J Clin Invest, 126 (10), p. 3981-3998, 2016, ISSN: 1558-8238 (Electronic) 0021-9738 (Linking).

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Guibert, N; Mazieres, J; Didier, A; Porte, S J; Projetti, F; Hermant, C

Tracheal Glomangioleiomyoma Treated by Multimodal Interventional Bronchoscopy Article de journal

Ann Thorac Surg, 101 (4), p. 1591-4, 2016, ISSN: 1552-6259 (Electronic) 0003-4975 (Linking).

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Guibert, N; Mhanna, L; Droneau, S; Plat, G; Didier, A; Mazieres, J; Hermant, C

Techniques of endoscopic airway tumor treatment Article de journal

J Thorac Dis, 8 (11), p. 3343-3360, 2016, ISSN: 2072-1439 (Print) 2072-1439 (Linking).

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Guilleminault, L; Just, J; Humbert, M; Leroyer, C; Epaud, R

[Seasonality in asthma: Impact and treatments] Article de journal

Presse Med, 45 (11), p. 1005-1018, 2016, ISSN: 2213-0276 (Electronic) 0755-4982 (Linking).

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Guilleminault, L; Laurent, S; Foucher, A; Poubeau, P; Paganin, F

Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication Article de journal

BMC Pulm Med, 16 (1), p. 72, 2016, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Laforest, L; Belhassen, M; Devouassoux, G; Didier, A; Ginoux, M; Van Ganse, E

Long-Term Inhaled Corticosteroid Adherence in Asthma Patients with Short-Term Adherence Article de journal

J Allergy Clin Immunol Pract, 4 (5), p. 890-899 e2, 2016, ISSN: 2213-2201 (Electronic).

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Marichal, T; Gaudenzio, N; El Abbas, S; Sibilano, R; Zurek, O; Starkl, P; Reber, L L; Pirottin, D; Kim, J; Chambon, P; Roers, A; Antoine, N; Kawakami, Y; Kawakami, T; Bureau, F; Tam, S Y; Tsai, M; Galli, S J

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis Article de journal

J Clin Invest, 126 (12), p. 4497-4515, 2016, ISSN: 1558-8238 (Electronic) 0021-9738 (Linking).

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Morelot-Panzini, C; Gilet, H; Aguilaniu, B; Devillier, P; Didier, A; Perez, T; Pignier, C; Arnould, B; Similowski, T

Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients Article de journal

Eur Respir J, 47 (6), p. 1668-79, 2016, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Rabeau, A; Mazieres, J; Hermant, C; Projetti, F; Didier, A; Guibert, N

Bronchoscopic Multimodal Management of Tracheal Neurofibroma Article de journal

J Bronchology Interv Pulmonol, 23 (4), p. 340-342, 2016, ISSN: 1948-8270 (Electronic) 1948-8270 (Linking).

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Reber, L L; Fahy, J V

Mast cells in asthma: biomarker and therapeutic target Article de journal

Eur Respir J, 47 (4), p. 1040-2, 2016, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Reber, L L; Gaudenzio, N; Starkl, P; Galli, S J

Neutrophils are not required for resolution of acute gouty arthritis in mice Article de journal

Nat Med, 22 (12), p. 1382-1384, 2016, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

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Respaud, R; Marchand, D; Pelat, T; Tchou-Wong, K M; Roy, C J; Parent, C; Cabrera, M; Guillemain, J; Mac Loughlin, R; Levacher, E; Fontayne, A; Douziech-Eyrolles, L; Junqua-Moullet, A; Guilleminault, L; Thullier, P; Guillot-Combe, E; Vecellio, L; Heuze-Vourc'h, N

Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin Article de journal

J Control Release, 234 , p. 21-32, 2016, ISSN: 1873-4995 (Electronic) 0168-3659 (Linking).

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Sibilano, R; Gaudenzio, N; DeGorter, M K; Reber, L L; Hernandez, J D; Starkl, P M; Zurek, O W; Tsai, M; Zahner, S; Montgomery, S B; Roers, A; Kronenberg, M; Yu, M; Galli, S J

A TNFRSF14-FcvarepsilonRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice Article de journal

Nat Commun, 7 , p. 13696, 2016, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Starkl, P; Marichal, T; Gaudenzio, N; Reber, L L; Sibilano, R; Tsai, M; Galli, S J

IgE antibodies, FcepsilonRIalpha, and IgE-mediated local anaphylaxis can limit snake venom toxicity Article de journal

J Allergy Clin Immunol, 137 (1), p. 246-257 e11, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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2015

Borgne, A L; Prevot, G; Rouquette, I; Huynh, A; Tetu, L; Projetti, F; Carreiro, M; Borie, R; Jaccard, A; Recher, C; Didier, A

Blood stem cell transplantation to treat cystic lung light chain deposition disease Article de journal

Eur Respir J, 46 (4), p. 1199-202, 2015, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Didier, A; Bons, B

Safety and tolerability of 5-grass pollen tablet sublingual immunotherapy: pooled analysis and clinical review Article de journal

Expert Opin Drug Saf, 14 (5), p. 777-88, 2015, ISSN: 1744-764X (Electronic) 1474-0338 (Linking).

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Didier, A; Campo, P; Moreno, F; Durand-Perdriel, F; Marin, A; Chartier, A

Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with Allergic Rhinitis Article de journal

Int Arch Allergy Immunol, 168 (3), p. 182-92, 2015, ISSN: 1423-0097 (Electronic) 1018-2438 (Linking).

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Didier, A; Malling, H J; Worm, M; Horak, F; Sussman, G L

Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score Article de journal

Clin Transl Allergy, 5 , p. 12, 2015, ISSN: 2045-7022 (Print) 2045-7022 (Linking).

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Gaillet, G; Favelle, O; Guilleminault, L; de Muret, A; Lemarie, E; Lecomte, T; Marchand-Adam, S; Diot, P

Gastroesophageal reflux disease is a risk factor for severity of organizing pneumonia Article de journal

Respiration, 89 (2), p. 119-26, 2015, ISSN: 1423-0356 (Electronic) 0025-7931 (Linking).

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Galli, S J; Tsai, M; Marichal, T; Tchougounova, E; Reber, L L; Pejler, G

Approaches for analyzing the roles of mast cells and their proteases in vivo Article de journal

Adv Immunol, 126 , p. 45-127, 2015, ISSN: 1557-8445 (Electronic) 0065-2776 (Linking).

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Gaudenzio, N; Sibilano, R; Starkl, P; Tsai, M; Galli, S J; Reber, L L

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice Article de journal

J Vis Exp, (99), p. e52753, 2015, ISSN: 1940-087X (Electronic) 1940-087X (Linking).

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Guibert, N; Mazieres, J; Marquette, C H; Rouviere, D; Didier, A; Hermant, C

Integration of interventional bronchoscopy in the management of lung cancer Article de journal

Eur Respir Rev, 24 (137), p. 378-91, 2015, ISSN: 1600-0617 (Electronic) 0905-9180 (Linking).

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Guilleminault, L; Carmier, D; Heuze-Vourc'h, N; Diot, P; Pichon, E

[Immunotherapy in non-small cell lung cancer: inhibition of PD1/PDL1 pathway] Article de journal

Rev Pneumol Clin, 71 (1), p. 44-56, 2015, ISSN: 0761-8417 (Print) 0761-8417 (Linking).

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Guilleminault, L; Sigmann, M H; Paganin, F

A good night for a bad day Article de journal

Thorax, 70 (6), p. 604, 607, 2015, ISSN: 1468-3296 (Electronic) 0040-6376 (Linking).

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Marchand, S; Bouchene, S; de Monte, M; Guilleminault, L; Montharu, J; Cabrera, M; Gregoire, N; Gobin, P; Diot, P; Couet, W; Vecellio, L

Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys Article de journal

Pharm Res, 32 (10), p. 3403-14, 2015, ISSN: 1573-904X (Electronic) 0724-8741 (Linking).

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Ogielska, M; Lanotte, P; Le Brun, C; Valentin, A S; Garot, D; Tellier, A C; Halimi, J M; Colombat, P; Guilleminault, L; Lioger, B; Vegas, H; De Toffol, B; Constans, T; Bernard, L

Emergence of community-acquired Clostridium difficile infection: the experience of a French hospital and review of the literature Article de journal

Int J Infect Dis, 37 , p. 36-41, 2015, ISSN: 1878-3511 (Electronic) 1201-9712 (Linking).

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Pillard, F; Lavit, M; Cances, V L; Rami, J; Houin, G; Didier, A; Riviere, D

Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes Article de journal

Respir Res, 16 , p. 155, 2015, ISSN: 1465-993X (Electronic) 1465-9921 (Linking).

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Provost, D; Iwatsubo, Y; Riviere, S; Mevel, M; Didier, A; Brochard, P; Imbernon, E; Raherison, C

The impact of allergic rhinitis on the management of asthma in a working population Article de journal

BMC Pulm Med, 15 , p. 142, 2015, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Roingeard, C; Jaubert, J; Guilleminault, L

A large and unusual lung abscess with positive culture to Slackia exigua Article de journal

Int J Infect Dis, 40 , p. 37-8, 2015, ISSN: 1878-3511 (Electronic) 1201-9712 (Linking).

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Sedkaoui, K; Leseux, L; Pontier, S; Rossin, N; Leophonte, P; Fraysse, J L; Didier, A

Efficiency of a phone coaching program on adherence to continuous positive airway pressure in sleep apnea hypopnea syndrome: a randomized trial Article de journal

BMC Pulm Med, 15 , p. 102, 2015, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Collaborations

Kari Nadeau, MD, PhD, Université de Stanford, USA

Stephen J. Galli, MD, Université de Stanford, USA

Philipp Starkl, PhD, CeMM, Vienne, Autriche

Thomas Marichal, PhD, GIGA Institute, Liège, Belgique

Dr Nicolas Gaudenzio, UDEAR, Toulouse

Dr Pierre Bruhns Institut Pasteur, Paris

Dr Friederike Jönsson, Institut Pasteur, Paris

Dr Thierry Rose, Institut Pasteur, Paris

Dr Géraldine Vogel, CSO NEOVACS, Paris

Dr Sophie GEORGIN-LAVIALLE, MCU-PH, INSERM U933, Hôpital Trousseau, Paris

Hal Hoffman, MD, UC San Diego, USA

Impact on the society

Allergies are major public health problems of increasing prevalence and for which there is, in most cases, no efficient long-term therapy. Our team studies the cellular and molecular mechanisms of allergies, in order to identify potential new therapeutic targets. We develop and test new immunotherapeutic approaches to treat allergic diseases. To do so, we analyze clinical samples from allergic patients and use “humanized” mouse models of allergies, which allow us to directly assess the efficiencies of innovative therapies targeting key human proteins involved in allergic reactions. Our team is composed of scientists and clinicians, which allows us to perform both basic and translational research on allergies.

ATIP-Avenir

ATIP-Avenir

ANR

ANR

Neovacs

Neovacs

INSERM

INSERM

CNRS

CNRS

UT3

UT3