Infection virale : persistance, réponse de l’hôte et physiopathologie

Responsable : J. Izopet

Objectifs Scientifiques


Notre laboratoire s’intéresse à la physiopathologie des infections par le virus de l’immunodéficience humaine (HIV), le virus de l’hépatite E (HEV) et le virus zika (ZIKV). Nous étudions les mécanismes de persistance de ces virus chez l’hôte immunocompétent (HIV, ZIKV) ou chez l’immunodéprimé (HEV). Nous étudions les mécanismes d’entrée du HIV par les récepteurs de chimiokines, ainsi que la physiopathologie de l’infection HIV dans la muqueuse intestinale. Nous étudions également de manière détaillée les modes de transmission et la pathogénèse du HEV et du ZIKV au cours de la grossesse. Nos travaux reposent sur des modèles cellulaires originaux (explants placentaires, cytotrophoblastes extravilleux primaires, hépatocytes, entérocytes, lymphocytes circulants et tissulaires) et des échantillons cliniques (tissu intestinal, placentas précoces et à terme, sang et biopsies de patients immunodéprimés).

Nos Projets


AXE 1: HIV

Nous nous intéressons à l’interaction du HIV avec les corécepteurs d’entrée, CCR5 et CXCR4 aux mécanismes qui sous-tendent l’entrée du VIH dans ses cellules cibles et à leur incidence sur la pathogénèse de l’infection et le développement du SIDA. Nous contribuons au développement et à l’étude du mode d’action d’inhibiteurs de l’entrée virale ciblant les récepteurs du virus (CD4, CCR5 ou CXCR4) ainsi que des mécanismes mis en jeu par les virus pour résister/échapper à l’action de ces inhibiteurs chez les patients.

Sous traitement antirétroviral, la restauration immunitaire est retardée et incomplète dans la muqueuse intestinale. Nous avons mis en évidence un défaut des axes de chimiotaxisme CCR9-CCL25 et CCR6-CCL20. Nous étudions l’impact de ces altérations sur les populations lymphocytaires Th17, Th1, Treg et TCD8+ et l’homéostasie muqueuse, notamment les interactions entre microbiote et inflammation.

AXE 2: HEV

Nous caractérisons la réponse immune dirigée contre le HEV (TCD4+, TCD8+, NK, T gamma-delta) chez les sujets immunodéprimés pouvant développer une hépatite chronique, au cours de la grossesse, et chez les sujets âgés présentant fréquemment des infections symptomatiques.

Nous étudions la diversité génétique du virus et l’impact de celle-ci sur la physiopathologie de l’infection, notamment au cours de la grossesse. Nous nous intéressons au cycle viral et étudions plus particulièrement les mécanismes de libération des virions. Après avoir démontré l’effet antiviral de la ribavirine sur le HEV, nous étudions à présent les mécanismes de résistance du virus à cette molécule au cours du traitement de l’hépatite E chronique.

AXE 3: ZIKV

Le développement d’une réponse immune adéquate et contrôlée est cruciale pour maintenir l’homéostasie de l’’organisme. Une réponse déséquilibrée peut conduire à des maladies auto-immunes si le système immunitaire réagit trop fortement ou permet une expansion tumorale due à une réponse immunitaire insuffisante.

Nous étudions la réplication du ZIKV dans le compartiment génital et au niveau de l’interface materno-fœtale. Nous avons montré que le ZIKV provoquait des lésions au niveau de la decidua basalis maternelle, du placenta fœtal et du cordon ombilical. Nous avons également observé que le virus infectait une grande diversité de cellules : les fibroblastes de la decidua, le trophoblaste et les cellules mésenchymateuses du cordon ombilical.

Nous avons montré que le virus était présent dans le sperme des patients infectés pendant une période prolongée et que les spermatozoïdes étaient porteurs d’antigènes viraux. Nous étudions à présent les mécanismes de persistance du virus dans le compartiment génital.

Autres informations


Publications

2019

Marion, O; Lhomme, S; Del Bello, A; Abravanel, F; Esposito, L; Hebral, A L; Lavayssiere, L; Cointault, O; Ribes, D; Izopet, J; Kamar, N

Monitoring hepatitis E virus fecal shedding to optimize ribavirin treatment duration in chronically infected transplant patients Article de journal

J Hepatol, 70 (1), p. 206-209, 2019, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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2018

Jin, J; Momboisse, F; Boncompain, G; Koensgen, F; Zhou, Z; Cordeiro, N; Arenzana-Seisdedos, F; Perez, F; Lagane, B; Kellenberger, E; Brelot, A

CCR5 adopts three homodimeric conformations that control cell surface delivery Article de journal

Sci Signal, 11 (529), 2018, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

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Colin, P; Zhou, Z; Staropoli, I; Garcia-Perez, J; Gasser, R; Armani-Tourret, M; Benureau, Y; Gonzalez, N; Jin, J; Connell, B J; Raymond, S; Delobel, P; Izopet, J; Lortat-Jacob, H; Alcami, J; Arenzana-Seisdedos, F; Brelot, A; Lagane, B

CCR5 structural plasticity shapes HIV-1 phenotypic properties Article de journal

PLoS Pathog, 14 (12), p. e1007432, 2018, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Gouilly, J; Chen, Q; Siewiera, J; Cartron, G; Levy, C; Dubois, M; Al-Daccak, R; Izopet, J; Jabrane-Ferrat, N; El Costa, H

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface Article de journal

Nat Commun, 9 (1), p. 4748, 2018, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Lopes, P P; Todorov, G; Pham, T T; Nesburn, A B; Bahraoui, E; BenMohamed, L

Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8(+) TEM and TRM Cell Responses against Herpesvirus Infection and Disease Article de journal

J Virol, 92 (8), 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Srivastava, R; Hernandez-Ruiz, M; Khan, A A; Fouladi, M A; Kim, G J; Ly, V T; Yamada, T; Lam, C; Sarain, S A B; Boldbaatar, U; Zlotnik, A; Bahraoui, E; BenMohamed, L

CXCL17 Chemokine-Dependent Mobilization of CXCR8(+)CD8(+) Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes Article de journal

J Immunol, 200 (8), p. 2915-2926, 2018, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Planes, R; Serrero, M; Leghmari, K; BenMohamed, L; Bahraoui, E

HIV-1 Envelope Glycoproteins Induce the Production of TNF-alpha and IL-10 in Human Monocytes by Activating Calcium Pathway Article de journal

Sci Rep, 8 (1), p. 17215, 2018, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Halfon, P; Scholtes, C; Izopet, J; Larrat, S; Trimoulet, P; Zoulim, F; Alric, L; Metivier, S; Leroy, V; Ouzan, D; de Ledinghen, V; Mohamed, S; Penaranda, G; Khiri, H; Thelu, M A; Plauzolles, A; Chiche, L; Bourliere, M; Abravanel, F

Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort Article de journal

Antivir Ther, 23 (4), p. 307-314, 2018, ISSN: 2040-2058 (Electronic) 1359-6535 (Linking).

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Montpellier, C; Wychowski, C; Sayed, I M; Meunier, J C; Saliou, J M; Ankavay, M; Bull, A; Pillez, A; Abravanel, F; Helle, F; Brochot, E; Drobecq, H; Farhat, R; Aliouat-Denis, C M; Haddad, J G; Izopet, J; Meuleman, P; Goffard, A; Dubuisson, J; Cocquerel, L

Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein Article de journal

Gastroenterology, 154 (1), p. 211-223 e8, 2018, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Halfon, P; Scholtes, C; Izopet, J; Larrat, S; Trimoulet, P; Zoulim, F; Alric, L; Metivier, S; Leroy, V; Ouzan, D; de Ledinghen, V; Mohamed, S; Penaranda, G; Khiri, H; Thelu, M A; Plauzolles, A; Chiche, L; Bourliere, M; Abravanel, F

Retreatment with direct-acting antivirals of genotypes 1-3-4 hepatitis C patients who failed an anti-NS5A regimen in real world Article de journal

J Hepatol, 68 (3), p. 595-597, 2018, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Kamar, N; Del Bello, A; Izopet, J

Should Persistent Hepatitis E Virus Replication in Transplant Patients Be Tolerated? Article de journal

Transplantation, 102 (2), p. e84-e85, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Raymond, S; Nicot, F; Pallier, C; Bellecave, P; Maillard, A; Trabaud, M A; Morand-Joubert, L; Rodallec, A; Amiel, C; Mourez, T; Bocket, L; Beby-Defaux, A; Bouvier-Alias, M; Lambert-Niclot, S; Charpentier, C; Malve, B; Mirand, A; Dina, J; Le Guillou-Guillemette, H; Marque-Juillet, S; Signori-Schmuck, A; Barin, F; Si-Mohamed, A; Avettand Fenoel, V; Roussel, C; Calvez, V; Saune, K; Marcelin, A G; Rodriguez, C; Descamps, D; Izopet, J; French National Agency for Research on, Aids ; Viral Hepatitis, Resistance Study Group A C

Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen Article de journal

Clin Infect Dis, 66 (10), p. 1588-1594, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Braun, P; Delgado, R; Drago, M; Fanti, D; Fleury, H; Izopet, J; Lombardi, A; Mancon, A; Marcos, M A; Saune, K; S, Shea O; Perez-Rivilla, A; Ramble, J; Trimoulet, P; Vila, J; Whittaker, D; Artus, A; Rhodes, D

A European multicenter study on the analytical performance of the VERIS HBV assay Article de journal

J Clin Virol, 99-100 , p. 50-56, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Raymond, S; Nicot, F; Carcenac, R; Lefebvre, C; Jeanne, N; Saune, K; Delobel, P; Izopet, J

HIV-1 genotypic resistance testing using the Vela automated next-generation sequencing platform Article de journal

J Antimicrob Chemother, 73 (5), p. 1152-1157, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Bisseux, M; Colombet, J; Mirand, A; Roque-Afonso, A M; Abravanel, F; Izopet, J; Archimbaud, C; Peigue-Lafeuille, H; Debroas, D; Bailly, J L; Henquell, C

Monitoring human enteric viruses in wastewater and relevance to infections encountered in the clinical setting: a one-year experiment in central France, 2014 to 2015 Article de journal

Euro Surveill, 23 (7), 2018, ISSN: 1560-7917 (Electronic) 1025-496X (Linking).

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Dalton, H R; Izopet, J

Transmission and Epidemiology of Hepatitis E Virus Genotype 3 and 4 Infections Article de journal

Cold Spring Harb Perspect Med, 8 (11), 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Mallet, V; Sberro-Soussan, R; Roque-Afonso, A M; Vallet-Pichard, A; Deau, B; Portal, A; Chaix, M L; Hauser, L; Beyloune, A; Mercadier, A; Izopet, J; Legendre, C; Pol, S

Transmission of Hepatitis E Virus With Plasma Exchange in Kidney Transplant Recipients: A Retrospective Cohort Study Article de journal

Transplantation, 102 (8), p. 1351-1357, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Kamar, N; Pischke, S

Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment Article de journal

Cold Spring Harb Perspect Med, 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Nicot, F; Jeanne, N; Raymond, S; Delfour, O; Carcenac, R; Lefebvre, C; Saune, K; Delobel, P; Izopet, J

Performance comparison of deep sequencing platforms for detecting HIV-1 variants in the pol gene Article de journal

J Med Virol, 90 (9), p. 1486-1492, 2018, ISSN: 1096-9071 (Electronic) 0146-6615 (Linking).

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Lambert-Niclot, S; Grude, M; Meynard, J L; Marcelin, A G; Valantin, M A; Flandre, P; Izopet, J; Moinot, L; Bouteloup, V; Calvez, V; Katlama, C; Girard, P M; Morand-Joubert, L

Ultrasensitive Human Immunodeficiency Virus Type 1 Viral Load as a Marker of Treatment Choice for Simplification Strategies Article de journal

Clin Infect Dis, 67 (12), p. 1883-1889, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Grellier, J; Hirsch, H H; Mengelle, C; Esposito, L; Hebral, A L; Belliere, J; Weissbach, F; Izopet, J; Del Bello, A; Kamar, N

Impact of donor BK polyomavirus replication on recipient infections in living donor transplantation Article de journal

Transpl Infect Dis, 20 (4), p. e12917, 2018, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Marion, O; Abravanel, F; Del Bello, A; Esposito, L; Lhomme, S; Puissant-Lubrano, B; Alric, L; Faguer, S; Izopet, J; Kamar, N

Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients Article de journal

Liver Int, 38 (12), p. 2178-2189, 2018, ISSN: 1478-3231 (Electronic) 1478-3223 (Linking).

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Nicot, F; Jeanne, N; Roulet, A; Lefebvre, C; Carcenac, R; Manno, M; Dubois, M; Kamar, N; Lhomme, S; Abravanel, F; Izopet, J

Diversity of hepatitis E virus genotype 3 Article de journal

Rev Med Virol, 28 (5), p. e1987, 2018, ISSN: 1099-1654 (Electronic) 1052-9276 (Linking).

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Abravanel, F; Lhomme, S; Chapuy-Regaud, S; Mansuy, J M; Boineau, J; Saune, K; Izopet, J

A fully automated system using transcription-mediated amplification for the molecular diagnosis of hepatitis E virus in human blood and faeces Article de journal

J Clin Virol, 105 , p. 109-111, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Abravanel, F; Pique, J; Couturier, E; Nicot, F; Dimeglio, C; Lhomme, S; Chiabrando, J; Saune, K; Peron, J M; Kamar, N; Evrard, S; de Valk, H; Cintas, P; Izopet, J; study , H E V

Acute hepatitis E in French patients and neurological manifestations Article de journal

J Infect, 77 (3), p. 220-226, 2018, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Mansuy, J M; Lhomme, S; Cazabat, M; Pasquier, C; Martin-Blondel, G; Izopet, J

Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR Article de journal

Diagn Microbiol Infect Dis, 92 (4), p. 284-287, 2018, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Raymond, S; Delaugerre, C; Nicot, F; Assoumou, L; Lancar, R; Beniguel, L; Izopet, J; study , Anrs Optimal

Accurate quantification of CXCR4-using HIV-1 variants by Illumina deep-sequencing Article de journal

AIDS, 32 (16), p. 2429-2431, 2018, ISSN: 1473-5571 (Electronic) 0269-9370 (Linking).

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Jadoul, M; Berenguer, M C; Doss, W; Fabrizi, F; Izopet, J; Jha, V; Kamar, N; Kasiske, B L; Lai, C L; Morales, J M; Patel, P R; Pol, S; Silva, M O; Balk, E M; Gordon, C E; Earley, A; Di, M; Martin, P

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management Article de journal

Kidney Int, 94 (4), p. 663-673, 2018, ISSN: 1523-1755 (Electronic) 0085-2538 (Linking).

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Abravanel, F; Lacipiere, A; Lhomme, S; Dubois, M; Minier, L; Peron, J M; Alric, L; Kamar, N; Izopet, J

Performance of a commercial assay for detecting and quantifying HEV RNA in faeces Article de journal

J Clin Virol, 109 , p. 1-5, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Capelli, N; Marion, O; Dubois, M; Allart, S; Bertrand-Michel, J; Lhomme, S; Abravanel, F; Izopet, J; Chapuy-Regaud, S

Vectorial Release of Hepatitis E Virus in Polarized Human Hepatocytes Article de journal

J Virol, 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Dimeglio, C; Beau, F; Broult, J; Gouy, P; Izopet, J; Lastere, S; Abravanel, F

Hepatitis E prevalence in French Polynesian blood donors Article de journal

PLoS One, 13 (12), p. e0208934, 2018, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Dimeglio, C; Raymond, S; Nicot, F; Jeanne, N; Carcenac, R; Lefebvre, C; Izopet, J; French National Agency for Research on, Aids ; Viral Hepatitis, Resistance Study Group A C

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen Article de journal

J Antimicrob Chemother, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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2017

Lhomme, S; Bardiaux, L; Abravanel, F; Gallian, P; Kamar, N; Izopet, J

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France Article de journal

Emerg Infect Dis, 23 (2), p. 353-356, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Hocine, H R; Costa, H E; Dam, N; Giustiniani, J; Palacios, I; Loiseau, P; Bensussan, A; Borlado, L R; Charron, D; Suberbielle, C; Jabrane-Ferrat, N; Al-Daccak, R

Minimizing the risk of allo-sensitization to optimize the benefit of allogeneic cardiac-derived stem/progenitor cells Article de journal

Sci Rep, 7 , p. 41125, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Dam, N; Hocine, H R; Palacios, I; DelaRosa, O; Menta, R; Charron, D; Bensussan, A; El Costa, H; Jabrane-Ferrat, N; Dalemans, W; Lombardo, E; Al-Daccak, R

Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair Article de journal

Front Immunol, 8 , p. 1413, 2017, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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Srivastava, R; Khan, A A; Chilukuri, S; Syed, S A; Tran, T T; Furness, J; Bahraoui, E; BenMohamed, L

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8(+) TEM and CD8(+) TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease Article de journal

J Virol, 91 (14), 2017, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Serrero, M; Planes, R; Bahraoui, E

PKC-delta isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-kappaB and CXCL8 production Article de journal

Sci Rep, 7 (1), p. 2384, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Donnelly, M C; Imlach, S N; Abravanel, F; Ramalingam, S; Johannessen, I; Petrik, J; Fraser, A R; Campbell, J D; Bramley, P; Dalton, H R; Hayes, P C; Kamar, N; Simpson, K J

Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient Article de journal

Gastroenterology, 152 (1), p. 300-301, 2017, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Abravanel, F; Lhomme, S; Fougere, M; Saune, K; Alvarez, M; Peron, J M; Delobel, P; Izopet, J

HEV infection in French HIV-infected patients Article de journal

J Infect, 74 (3), p. 310-313, 2017, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Raymond, S; Nicot, F; Jeanne, N; Delfour, O; Carcenac, R; Lefebvre, C; Cazabat, M; Saune, K; Delobel, P; Izopet, J

Performance comparison of next-generation sequencing platforms for determining HIV-1 coreceptor use Article de journal

Sci Rep, 7 , p. 42215, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Sayed, I M; Foquet, L; Verhoye, L; Abravanel, F; Farhoudi, A; Leroux-Roels, G; Izopet, J; Meuleman, P

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma Article de journal

Antiviral Res, 141 , p. 150-154, 2017, ISSN: 1872-9096 (Electronic) 0166-3542 (Linking).

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Abravanel, F; Goutagny, N; Perret, C; Lhomme, S; Vischi, F; Aversenq, A; Chapel, A; Dehainault, N; Piga, N; Dupret-Carruel, J; Izopet, J

Evaluation of two VIDAS ((R))prototypes for detecting anti-HEV IgG Article de journal

J Clin Virol, 89 , p. 46-50, 2017, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Mansuy, J M; Mengelle, C; Pasquier, C; Chapuy-Regaud, S; Delobel, P; Martin-Blondel, G; Izopet, J

Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens Article de journal

Emerg Infect Dis, 23 (5), p. 863-865, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Pasquier, C; Saune, K; Raymond, S; Boisneau, J; Courtade, M; Izopet, J

Comparison of Cobas(R) HPV and Anyplex II HPV28 assays for detecting and genotyping human papillomavirus Article de journal

Diagn Microbiol Infect Dis, 87 (1), p. 25-27, 2017, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Kamar, N; Wang, W; Dalton, H R; Pan, Q

Direct-acting antiviral therapy for hepatitis E virus? Article de journal

Lancet Gastroenterol Hepatol, 2 (3), p. 154-155, 2017, ISSN: 2468-1253 (Electronic).

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Velay, A; Kack-Kack, W; Abravanel, F; Lhomme, S; Leyendecker, P; Kremer, L; Chamouard, P; Izopet, J; Fafi-Kremer, S; Barth, H

Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient Article de journal

J Neurovirol, 23 (4), p. 615-620, 2017, ISSN: 1538-2443 (Electronic) 1355-0284 (Linking).

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Chapuy-Regaud, S; Dubois, M; Plisson-Chastang, C; Bonnefois, T; Lhomme, S; Bertrand-Michel, J; You, B; Simoneau, S; Gleizes, P E; Flan, B; Abravanel, F; Izopet, J

Characterization of the lipid envelope of exosome encapsulated HEV particles protected from the immune response Article de journal

Biochimie, 141 , p. 70-79, 2017, ISSN: 1638-6183 (Electronic) 0300-9084 (Linking).

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Dorr, G; Del Bello, A; Abravanel, F; Marion, O; Cointault, O; Ribes, D; Lavayssiere, L; Esposito, L; Nogier, M B; Hebral, A L; Saune, K; Izopet, J; Kamar, N

Malignancies in hepatitis C virus-positive and -negative kidney transplant recipients: A case-controlled study Article de journal

Transpl Infect Dis, 19 (4), 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Yin, X; Li, X; Ambardekar, C; Hu, Z; Lhomme, S; Feng, Z

Hepatitis E virus persists in the presence of a type III interferon response Article de journal

PLoS Pathog, 13 (5), p. e1006417, 2017, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Metsu, D; Toutain, P L; Chatelut, E; Delobel, P; Gandia, P

Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle? Article de journal

J Antimicrob Chemother, 72 (9), p. 2407-2409, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Abravanel, F; Lhomme, S; El Costa, H; Schvartz, B; Peron, J M; Kamar, N; Izopet, J

Rabbit Hepatitis E Virus Infections in Humans, France Article de journal

Emerg Infect Dis, 23 (7), p. 1191-1193, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Moulin, M; Alguacil, J; Gu, S; Mehtougui, A; Adams, E J; Peyrottes, S; Champagne, E

Vgamma9Vdelta2 T cell activation by strongly agonistic nucleotidic phosphoantigens Article de journal

Cell Mol Life Sci, 74 (23), p. 4353-4367, 2017, ISSN: 1420-9071 (Electronic) 1420-682X (Linking).

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Izopet, J; Lhomme, S; Chapuy-Regaud, S; Mansuy, J M; Kamar, N; Abravanel, F

HEV and transfusion-recipient risk Article de journal

Transfus Clin Biol, 24 (3), p. 176-181, 2017, ISSN: 1953-8022 (Electronic) 1246-7820 (Linking).

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Dalton, H R; van Eijk, J J J; Cintas, P; Madden, R G; Jones, C; Webb, G W; Norton, B; Pique, J; Lutgens, S; Devooght-Johnson, N; Woolson, K; Baker, J; Saunders, M; Househam, L; Griffiths, J; Abravanel, F; Izopet, J; Kamar, N; van Alfen, N; van Engelen, B G M; Hunter, J G; van der Eijk, A A; Bendall, R P; McLean, B N; Jacobs, B C

Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study Article de journal

J Hepatol, 67 (5), p. 925-932, 2017, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Joguet, G; Mansuy, J M; Matusali, G; Hamdi, S; Walschaerts, M; Pavili, L; Guyomard, S; Prisant, N; Lamarre, P; Dejucq-Rainsford, N; Pasquier, C; Bujan, L

Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Article de journal

Lancet Infect Dis, 17 (11), p. 1200-1208, 2017, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Pasquier, C; Walschaerts, M; Raymond, S; Moinard, N; Saune, K; Daudin, M; Izopet, J; Bujan, L

Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy Article de journal

Basic Clin Androl, 27 , p. 17, 2017, ISSN: 2051-4190 (Print) 2051-4190 (Linking).

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Barrague, H; Condat, B; Petitdidier, N; Champagne, E; Renou, C; Izopet, J; Abravanel, F

Chronic hepatitis E virus infection in a cirrhotic patient: A case report Article de journal

Medicine (Baltimore), 96 (39), p. e7915, 2017, ISSN: 1536-5964 (Electronic) 0025-7974 (Linking).

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Belliere, J; Abravanel, F; Nogier, M B; Martinez, S; Cintas, P; Lhomme, S; Lavayssiere, L; Cointault, O; Faguer, S; Izopet, J; Kamar, N

Transfusion-acquired hepatitis E infection misdiagnosed as severe critical illness polyneuromyopathy in a heart transplant patient Article de journal

Transpl Infect Dis, 19 (6), 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Kamar, N; Izopet, J; Pavio, N; Aggarwal, R; Labrique, A; Wedemeyer, H; Dalton, H R

Hepatitis E virus infection Article de journal

Nat Rev Dis Primers, 3 , p. 17086, 2017, ISSN: 2056-676X (Electronic) 2056-676X (Linking).

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de Truchis, P; Assoumou, L; Landman, R; Mathez, D; Le Du, D; Bellet, J; Amat, K; Katlama, C; Gras, G; Bouchaud, O; Duracinsky, M; Abe, E; Alvarez, J C; Izopet, J; Saillard, J; Melchior, J C; Leibowitch, J; Costagliola, D; Girard, P M; Perronne, C; Group, Anrs Study D

Four-days-a-week antiretroviral maintenance therapy in virologically controlled HIV-1-infected adults: the ANRS 162-4D trial Article de journal

J Antimicrob Chemother, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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2016

Abravanel, F; Barrague, H; Dorr, G; Saune, K; Peron, J M; Alric, L; Kamar, N; Izopet, J; Champagne, E

Conventional and innate lymphocytes response at the acute phase of HEV infection in transplanted patients Article de journal

J Infect, 72 (6), p. 723-730, 2016, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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El Costa, H; Gouilly, J; Mansuy, J M; Chen, Q; Levy, C; Cartron, G; Veas, F; Al-Daccak, R; Izopet, J; Jabrane-Ferrat, N

ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy Article de journal

Sci Rep, 6 , p. 35296, 2016, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Gasser, R; Hamoudi, M; Pellicciotta, M; Zhou, Z; Visdeloup, C; Colin, P; Braibant, M; Lagane, B; Negroni, M

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions Article de journal

Retrovirology, 13 (1), p. 50, 2016, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Loiseau, C; Requena, M; Mavigner, M; Cazabat, M; Carrere, N; Suc, B; Barange, K; Alric, L; Marchou, B; Massip, P; Izopet, J; Delobel, P

CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals Article de journal

Mucosal Immunol, 9 (5), p. 1137-50, 2016, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

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Mansuy, J M; Dutertre, M; Mengelle, C; Fourcade, C; Marchou, B; Delobel, P; Izopet, J; Martin-Blondel, G

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Article de journal

Lancet Infect Dis, 16 (4), p. 405, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Benureau, Y; Colin, P; Staropoli, I; Gonzalez, N; Garcia-Perez, J; Alcami, J; Arenzana-Seisdedos, F; Lagane, B

Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins Article de journal

J Virol Methods, 236 , p. 184-95, 2016, ISSN: 1879-0984 (Electronic) 0166-0934 (Linking).

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Planes, R; Ben Haij, N; Leghmari, K; Serrero, M; BenMohamed, L; Bahraoui, E

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes Article de journal

J Virol, 90 (13), p. 5886-5898, 2016, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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2015

Garcia-Perez, J; Staropoli, I; Azoulay, S; Heinrich, J T; Cascajero, A; Colin, P; Lortat-Jacob, H; Arenzana-Seisdedos, F; Alcami, J; Kellenberger, E; Lagane, B

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity Article de journal

Retrovirology, 12 , p. 50, 2015, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Jeanne, N; Saliou, A; Carcenac, R; Lefebvre, C; Dubois, M; Cazabat, M; Nicot, F; Loiseau, C; Raymond, S; Izopet, J; Delobel, P

Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism Article de journal

Sci Rep, 5 , p. 16944, 2015, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Lhomme, S; Kamar, N; Nicot, F; Ducos, J; Bismuth, M; Garrigue, V; Petitjean-Lecherbonnier, J; Ollivier, I; Alessandri-Gradt, E; Goria, O; Barth, H; Perrin, P; Saune, K; Dubois, M; Carcenac, R; Lefebvre, C; Jeanne, N; Abravanel, F; Izopet, J

Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy Article de journal

Antimicrob Agents Chemother, 60 (3), p. 1608-14, 2015, ISSN: 1098-6596 (Electronic) 0066-4804 (Linking).

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Siewiera, J; Gouilly, J; Hocine, H R; Cartron, G; Levy, C; Al-Daccak, R; Jabrane-Ferrat, N

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes Article de journal

Nat Commun, 6 , p. 10183, 2015, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Ben Haij, N; Planes, R; Leghmari, K; Serrero, M; Delobel, P; Izopet, J; BenMohamed, L; Bahraoui, E

HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-kappaB Pathway Article de journal

PLoS One, 10 (6), p. e0129425, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Ainaoui, N; Hantelys, F; Renaud-Gabardos, E; Bunel, M; Lopez, F; Pujol, F; Planes, R; Bahraoui, E; Pichereaux, C; Burlet-Schiltz, O; Parini, A; Garmy-Susini, B; Prats, A C

Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation Article de journal

PLoS One, 10 (9), p. e0136466, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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2014

Kamar, N; Izopet, J; Tripon, S; Bismuth, M; Hillaire, S; Dumortier, J; Radenne, S; Coilly, A; Garrigue, V; D'Alteroche, L; Buchler, M; Couzi, L; Lebray, P; Dharancy, S; Minello, A; Hourmant, M; Roque-Afonso, A M; Abravanel, F; Pol, S; Rostaing, L; Mallet, V

Ribavirin for chronic hepatitis E virus infection in transplant recipients Article de journal

N Engl J Med, 370 (12), p. 1111-20, 2014, ISSN: 1533-4406 (Electronic) 0028-4793 (Linking).

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Jabrane-Ferrat, N; Siewiera, J

The up side of decidual natural killer cells: new developments in immunology of pregnancy Article de journal

Immunology, 141 (4), p. 490-7, 2014, ISSN: 1365-2567 (Electronic) 0019-2805 (Linking).

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Lauden, L; Siewiera, J; Boukouaci, W; Ramgolam, K; Mourah, S; Lebbe, C; Charron, D; Aoudjit, F; Jabrane-Ferrat, N; Al-Daccak, R

TGF-beta-induced (TGFBI) protein in melanoma: a signature of high metastatic potential Article de journal

J Invest Dermatol, 134 (6), p. 1675-1685, 2014, ISSN: 1523-1747 (Electronic) 0022-202X (Linking).

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Boukouaci, W; Lauden, L; Siewiera, J; Dam, N; Hocine, H R; Khaznadar, Z; Tamouza, R; Borlado, L R; Charron, D; Jabrane-Ferrat, N; Al-Daccak, R

Natural killer cell crosstalk with allogeneic human cardiac-derived stem/progenitor cells controls persistence Article de journal

Cardiovasc Res, 104 (2), p. 290-302, 2014, ISSN: 1755-3245 (Electronic) 0008-6363 (Linking).

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Planes, R; BenMohamed, L; Leghmari, K; Delobel, P; Izopet, J; Bahraoui, E

HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms Article de journal

J Virol, 88 (12), p. 6672-89, 2014, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Bahraoui, E; Briant, L; Chazal, N

E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein Article de journal

Virol J, 11 , p. 214, 2014, ISSN: 1743-422X (Electronic) 1743-422X (Linking).

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Impact sociétal

Connaissance de la biologie des virus à ARN et des mécanismes pathologiques

Notre recherche génère des connaissances fondamentales mais aussi des applications thérapeutiques sur des infections chroniques (HIV et HEV) ou émergentes (ZIKV) dont la physiopathologie reste à préciser. Les liens étroits avec les services cliniques du CHU de Toulouse et les plateaux techniques du CPTP assurent une réactivité optimale pour le développement de thématiques originales.

Alumni

H. Barragué (doctorant)
R. Gasser (post-doc)
J. Gouilly (doctorant)

INSERM

INSERM

CNRS

CNRS

ANRS

ANRS

Sidaction

Sidaction

Hôpitaux de Toulouse

Hôpitaux de Toulouse

Agence de la biomédecine

Agence de la biomédecine