Viral infection : persistence, host response and pathophysiology

Coordinator : J. Izopet

Scientific Objectives


Our team specializes in the pathophysiology of infections with human immunodeficiency virus (HIV), hepatitis E virus (HEV) and zika virus (ZIKV). The major specific topic is the mechanisms underlying the persistence of virus in immunocompetent hosts (HIV, ZIKV) and immunocompromised patients (HEV). We are also working on how HIV enters host cells via chemokine receptors and the pathophysiology of HIV infection in the intestinal mucosa. Another aspect of our work is the route of transmission and pathogenesis of HEV and ZIKV during pregnancy. We have developed a number of specific model cell systems, including placental explants, extravillous cytotrophoblasts, hepatocytes, enterocytes, peripheral and tissue lymphocytes, together with systems based on clinical samples (intestinal tissue, early and term placenta, blood and biopsies from immunocompromised patients).

Our projects


AXIS 1: HIV

We are interested in the mechanisms underlying HIV entry into target cells and their impact on the pathogenesis of infection and the development of AIDS. We are contributing to the design and study of how entry inhibitors direct against HIV receptors (CD4, CCR5 or CXCR4) act and the way in which the virus resist/escape to the action of these inhibitors.

The immune restoration of the intestinal mucosa of patient on antiretroviral therapy is delayed and incomplete. We have shown that the chemiotaxis axis CCR9-CCL25 and CCR6-CCL20 is altered and are now determining the impact of these alteration on the populations of Th17, Th1, Treg and TCD8 lymphocytes.

AXIS 2: HEV

Other members of the team are characterizing the immune response to HEV (TCD4+, TCD8+, NK, T gamma-delta) in subjects such as immunocompromised hosts, pregnant women and the elderly, who frequently present with symptomatic infections.

This includes determining the genetic diversity of the virus and its impact on pathogenesis, particularly during pregnancy. We are interested in the virus life cycle, particularly how the virus leaves infected cells. We have already demonstrated that ribavirin has an antiviral effect on HEV and we are now investigating how the virus becomes resistant to this drug during the treatment of chronic hepatitis E.

AXIS 3: ZIKV

We are studying the replication of ZIKV in the genital compartment and at the maternofetal interface. We have evidence that ZIKV replicates differentially in a wide range of maternal and fetal cells, including decidual fibroblasts and macrophages, trophoblasts and umbilical cord mesenchymal stem cells.

Our latest results show that the virus persists in the semen of infected patients for a long time and that the spermatozoa bear viral antigens. We are now looking at the mechanisms the virus uses to persist in the genital compartment.

Other details


Publications

2019

Marion, O; Lhomme, S; Del Bello, A; Abravanel, F; Esposito, L; Hebral, A L; Lavayssiere, L; Cointault, O; Ribes, D; Izopet, J; Kamar, N

Monitoring hepatitis E virus fecal shedding to optimize ribavirin treatment duration in chronically infected transplant patients Journal Article

J Hepatol, 70 (1), pp. 206-209, 2019, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Assoumou, L; Bocket, L; Pallier, C; Grude, M; Ait-Namane, R; Izopet, J; Raymond, S; Charpentier, C; Visseaux, B; Wirden, M; Trabaud, M A; Le Guillou-Guillemette, H; Allaoui, C; Henquell, C; Krivine, A; Dos Santos, G; Delamare, C; Bouvier-Alias, M; Montes, B; Ferre, V; De Monte, A; Signori-Schmuck, A; Maillard, A; Morand-Joubert, L; Tumiotto, C; Fafi-Kremer, S; Amiel, C; Barin, F; Marque-Juillet, S; Courdavault, L; Vallet, S; Beby-Defaux, A; de Rougemont, A; Fenaux, H; Avettand-Fenoel, V; Allardet-Servent, A; Plantier, J C; Peytavin, G; Calvez, V; Chaix, M L; Descamps, D; Group, Anrs Ac- Resistance Study

Stable prevalence of transmitted drug resistance mutations and increased circulation of non-B subtypes in antiretroviral-naive chronically HIV-infected patients in 2015/2016 in France Journal Article

J Antimicrob Chemother, 2019, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Dimeglio, C; Kania, D; Mantono, J M; Kagone, T; Zida, S; Tassembedo, S; Dicko, A; Tinto, B; Yaro, S; Hien, H; Rouamba, J; Bicaba, B; Medah, I; Meda, N; Traore, O; Tuaillon, E; Abravanel, F; Izopet, J

Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso Journal Article

Viruses, 11 (6), 2019, ISSN: 1999-4915 (Electronic) 1999-4915 (Linking).

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Dimeglio, C; Raymond, S; Nicot, F; Jeanne, N; Carcenac, R; Lefebvre, C; Izopet, J; French National Agency for Research on, Aids ; Viral Hepatitis, Resistance Study Group A C

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen Journal Article

J Antimicrob Chemother, 74 (3), pp. 718-721, 2019, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Dukhovny, A; Lamkiewicz, K; Chen, Q; Fricke, M; Jabrane-Ferrat, N; Marz, M; Jung, J U; Sklan, E H

A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection Journal Article

J Virol, 93 (16), 2019, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Guerveno, C; Raymond, S; Metsu, D; Gandia, P; Izopet, J; Martin-Blondel, G; Delobel, P

HIV-1 escape in the central nervous system on elvitegravir-based antiretroviral therapy Journal Article

AIDS, 33 (3), pp. 593-594, 2019, ISSN: 1473-5571 (Electronic) 0269-9370 (Linking).

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Hocine, H R; Brunel, S; Chen, Q; Giustiniani, J; San Roman, M J; Ferrat, Y J; Palacios, I; de la Rosa, O; Lombardo, E; Bensussan, A; Charron, D; Jabrane-Ferrat, N; Al-Daccak, R

Extracellular Vesicles Released by Allogeneic Human Cardiac Stem/Progenitor Cells as Part of Their Therapeutic Benefit Journal Article

Stem Cells Transl Med, 8 (9), pp. 911-924, 2019, ISSN: 2157-6580 (Electronic) 2157-6564 (Linking).

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Jabrane-Ferrat, N

Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection Journal Article

Front Immunol, 10 , pp. 1397, 2019, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

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Lhomme, S; DebRoy, S; Kamar, N; Abravanel, F; Metsu, D; Marion, O; Dimeglio, C; Cotler, S J; Izopet, J; Dahari, H

Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin Journal Article

Viruses, 11 (7), 2019, ISSN: 1999-4915 (Electronic) 1999-4915 (Linking).

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Lhomme, S; Gallian, P; Dimeglio, C; Assal, A; Abravanel, F; Tiberghien, P; Izopet, J

Viral load and clinical manifestations of hepatitis E virus genotype 3 infections Journal Article

J Viral Hepat, 26 (9), pp. 1139-1142, 2019, ISSN: 1365-2893 (Electronic) 1352-0504 (Linking).

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Loiseau, C; Requena, M; Nayrac, M; Mavigner, M; Cazabat, M; Iscache, A L; Carrere, N; Suc, B; Alric, L; Izopet, J; Delobel, P

Increased CXCR3+ T Cells Impairs Recruitment of T-Helper Type 17 Cells via Interferon gamma and Interleukin 18 in the Small Intestine Mucosa During Treated HIV-1 Infection Journal Article

J Infect Dis, 220 (5), pp. 830-840, 2019, ISSN: 1537-6613 (Electronic) 0022-1899 (Linking).

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Mansuy, J M; El Costa, H; Gouilly, J; Mengelle, C; Pasquier, C; Martin-Blondel, G; Izopet, J; Jabrane-Ferrat, N

Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans Journal Article

Emerg Infect Dis, 25 (4), pp. 823-825, 2019, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Marion, O; Capelli, N; Lhomme, S; Dubois, M; Pucelle, M; Abravanel, F; Kamar, N; Izopet, J

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients Journal Article

J Infect, 78 (3), pp. 232-240, 2019, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Mzoughi, O; Teixido, M; Planes, R; Serrero, M; Hamimed, I; Zurita, E; Moreno, M; Granados, G; Lakhdar-Ghazal, F; BenMohamed, L; Giralt, E; Bahraoui, E

Trimeric Heptad Repeat Synthetic Peptides HR1 and HR2 Efficiently Inhibit HIV-1 Entry Journal Article

Biosci Rep, 2019, ISSN: 1573-4935 (Electronic) 0144-8463 (Linking).

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Sayed, I M; Verhoye, L; Montpellier, C; Abravanel, F; Izopet, J; Cocquerel, L; Meuleman, P

Hepatitis E Virus (HEV) Open Reading Frame 2 Antigen Kinetics in Human-Liver Chimeric Mice and Its Impact on HEV Diagnosis Journal Article

J Infect Dis, 220 (5), pp. 811-819, 2019, ISSN: 1537-6613 (Electronic) 0022-1899 (Linking).

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Souriant, S; Balboa, L; Dupont, M; Pingris, K; Kviatcovsky, D; Cougoule, C; Lastrucci, C; Bah, A; Gasser, R; Poincloux, R; Raynaud-Messina, B; Al Saati, T; Inwentarz, S; Poggi, S; Morana, E J; Gonzalez-Montaner, P; Corti, M; Lagane, B; Vergne, I; Allers, C; Kaushal, D; Kuroda, M J; Sasiain, M D C; Neyrolles, O; Maridonneau-Parini, I; Lugo-Villarino, G; Verollet, C

Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages Journal Article

Cell Rep, 26 (13), pp. 3586-3599 e7, 2019, ISSN: 2211-1247 (Electronic).

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2018

Jin, J; Momboisse, F; Boncompain, G; Koensgen, F; Zhou, Z; Cordeiro, N; Arenzana-Seisdedos, F; Perez, F; Lagane, B; Kellenberger, E; Brelot, A

CCR5 adopts three homodimeric conformations that control cell surface delivery Journal Article

Sci Signal, 11 (529), 2018, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

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Colin, P; Zhou, Z; Staropoli, I; Garcia-Perez, J; Gasser, R; Armani-Tourret, M; Benureau, Y; Gonzalez, N; Jin, J; Connell, B J; Raymond, S; Delobel, P; Izopet, J; Lortat-Jacob, H; Alcami, J; Arenzana-Seisdedos, F; Brelot, A; Lagane, B

CCR5 structural plasticity shapes HIV-1 phenotypic properties Journal Article

PLoS Pathog, 14 (12), pp. e1007432, 2018, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Gouilly, J; Chen, Q; Siewiera, J; Cartron, G; Levy, C; Dubois, M; Al-Daccak, R; Izopet, J; Jabrane-Ferrat, N; El Costa, H

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface Journal Article

Nat Commun, 9 (1), pp. 4748, 2018, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Lopes, P P; Todorov, G; Pham, T T; Nesburn, A B; Bahraoui, E; BenMohamed, L

Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8(+) TEM and TRM Cell Responses against Herpesvirus Infection and Disease Journal Article

J Virol, 92 (8), 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Srivastava, R; Hernandez-Ruiz, M; Khan, A A; Fouladi, M A; Kim, G J; Ly, V T; Yamada, T; Lam, C; Sarain, S A B; Boldbaatar, U; Zlotnik, A; Bahraoui, E; BenMohamed, L

CXCL17 Chemokine-Dependent Mobilization of CXCR8(+)CD8(+) Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes Journal Article

J Immunol, 200 (8), pp. 2915-2926, 2018, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Planes, R; Serrero, M; Leghmari, K; BenMohamed, L; Bahraoui, E

HIV-1 Envelope Glycoproteins Induce the Production of TNF-alpha and IL-10 in Human Monocytes by Activating Calcium Pathway Journal Article

Sci Rep, 8 (1), pp. 17215, 2018, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Halfon, P; Scholtes, C; Izopet, J; Larrat, S; Trimoulet, P; Zoulim, F; Alric, L; Metivier, S; Leroy, V; Ouzan, D; de Ledinghen, V; Mohamed, S; Penaranda, G; Khiri, H; Thelu, M A; Plauzolles, A; Chiche, L; Bourliere, M; Abravanel, F

Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort Journal Article

Antivir Ther, 23 (4), pp. 307-314, 2018, ISSN: 2040-2058 (Electronic) 1359-6535 (Linking).

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Montpellier, C; Wychowski, C; Sayed, I M; Meunier, J C; Saliou, J M; Ankavay, M; Bull, A; Pillez, A; Abravanel, F; Helle, F; Brochot, E; Drobecq, H; Farhat, R; Aliouat-Denis, C M; Haddad, J G; Izopet, J; Meuleman, P; Goffard, A; Dubuisson, J; Cocquerel, L

Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein Journal Article

Gastroenterology, 154 (1), pp. 211-223 e8, 2018, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Halfon, P; Scholtes, C; Izopet, J; Larrat, S; Trimoulet, P; Zoulim, F; Alric, L; Metivier, S; Leroy, V; Ouzan, D; de Ledinghen, V; Mohamed, S; Penaranda, G; Khiri, H; Thelu, M A; Plauzolles, A; Chiche, L; Bourliere, M; Abravanel, F

Retreatment with direct-acting antivirals of genotypes 1-3-4 hepatitis C patients who failed an anti-NS5A regimen in real world Journal Article

J Hepatol, 68 (3), pp. 595-597, 2018, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Kamar, N; Del Bello, A; Izopet, J

Should Persistent Hepatitis E Virus Replication in Transplant Patients Be Tolerated? Journal Article

Transplantation, 102 (2), pp. e84-e85, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Raymond, S; Nicot, F; Pallier, C; Bellecave, P; Maillard, A; Trabaud, M A; Morand-Joubert, L; Rodallec, A; Amiel, C; Mourez, T; Bocket, L; Beby-Defaux, A; Bouvier-Alias, M; Lambert-Niclot, S; Charpentier, C; Malve, B; Mirand, A; Dina, J; Le Guillou-Guillemette, H; Marque-Juillet, S; Signori-Schmuck, A; Barin, F; Si-Mohamed, A; Avettand Fenoel, V; Roussel, C; Calvez, V; Saune, K; Marcelin, A G; Rodriguez, C; Descamps, D; Izopet, J; French National Agency for Research on, Aids ; Viral Hepatitis, Resistance Study Group A C

Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen Journal Article

Clin Infect Dis, 66 (10), pp. 1588-1594, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Braun, P; Delgado, R; Drago, M; Fanti, D; Fleury, H; Izopet, J; Lombardi, A; Mancon, A; Marcos, M A; Saune, K; S, Shea O; Perez-Rivilla, A; Ramble, J; Trimoulet, P; Vila, J; Whittaker, D; Artus, A; Rhodes, D

A European multicenter study on the analytical performance of the VERIS HBV assay Journal Article

J Clin Virol, 99-100 , pp. 50-56, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Raymond, S; Nicot, F; Carcenac, R; Lefebvre, C; Jeanne, N; Saune, K; Delobel, P; Izopet, J

HIV-1 genotypic resistance testing using the Vela automated next-generation sequencing platform Journal Article

J Antimicrob Chemother, 73 (5), pp. 1152-1157, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Bisseux, M; Colombet, J; Mirand, A; Roque-Afonso, A M; Abravanel, F; Izopet, J; Archimbaud, C; Peigue-Lafeuille, H; Debroas, D; Bailly, J L; Henquell, C

Monitoring human enteric viruses in wastewater and relevance to infections encountered in the clinical setting: a one-year experiment in central France, 2014 to 2015 Journal Article

Euro Surveill, 23 (7), 2018, ISSN: 1560-7917 (Electronic) 1025-496X (Linking).

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Dalton, H R; Izopet, J

Transmission and Epidemiology of Hepatitis E Virus Genotype 3 and 4 Infections Journal Article

Cold Spring Harb Perspect Med, 8 (11), 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Mallet, V; Sberro-Soussan, R; Roque-Afonso, A M; Vallet-Pichard, A; Deau, B; Portal, A; Chaix, M L; Hauser, L; Beyloune, A; Mercadier, A; Izopet, J; Legendre, C; Pol, S

Transmission of Hepatitis E Virus With Plasma Exchange in Kidney Transplant Recipients: A Retrospective Cohort Study Journal Article

Transplantation, 102 (8), pp. 1351-1357, 2018, ISSN: 1534-6080 (Electronic) 0041-1337 (Linking).

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Kamar, N; Pischke, S

Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment Journal Article

Cold Spring Harb Perspect Med, 2018, ISSN: 2157-1422 (Electronic) 2157-1422 (Linking).

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Nicot, F; Jeanne, N; Raymond, S; Delfour, O; Carcenac, R; Lefebvre, C; Saune, K; Delobel, P; Izopet, J

Performance comparison of deep sequencing platforms for detecting HIV-1 variants in the pol gene Journal Article

J Med Virol, 90 (9), pp. 1486-1492, 2018, ISSN: 1096-9071 (Electronic) 0146-6615 (Linking).

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Lambert-Niclot, S; Grude, M; Meynard, J L; Marcelin, A G; Valantin, M A; Flandre, P; Izopet, J; Moinot, L; Bouteloup, V; Calvez, V; Katlama, C; Girard, P M; Morand-Joubert, L

Ultrasensitive Human Immunodeficiency Virus Type 1 Viral Load as a Marker of Treatment Choice for Simplification Strategies Journal Article

Clin Infect Dis, 67 (12), pp. 1883-1889, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Grellier, J; Hirsch, H H; Mengelle, C; Esposito, L; Hebral, A L; Belliere, J; Weissbach, F; Izopet, J; Del Bello, A; Kamar, N

Impact of donor BK polyomavirus replication on recipient infections in living donor transplantation Journal Article

Transpl Infect Dis, 20 (4), pp. e12917, 2018, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Marion, O; Abravanel, F; Del Bello, A; Esposito, L; Lhomme, S; Puissant-Lubrano, B; Alric, L; Faguer, S; Izopet, J; Kamar, N

Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients Journal Article

Liver Int, 38 (12), pp. 2178-2189, 2018, ISSN: 1478-3231 (Electronic) 1478-3223 (Linking).

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Nicot, F; Jeanne, N; Roulet, A; Lefebvre, C; Carcenac, R; Manno, M; Dubois, M; Kamar, N; Lhomme, S; Abravanel, F; Izopet, J

Diversity of hepatitis E virus genotype 3 Journal Article

Rev Med Virol, 28 (5), pp. e1987, 2018, ISSN: 1099-1654 (Electronic) 1052-9276 (Linking).

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Abravanel, F; Lhomme, S; Chapuy-Regaud, S; Mansuy, J M; Boineau, J; Saune, K; Izopet, J

A fully automated system using transcription-mediated amplification for the molecular diagnosis of hepatitis E virus in human blood and faeces Journal Article

J Clin Virol, 105 , pp. 109-111, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Abravanel, F; Pique, J; Couturier, E; Nicot, F; Dimeglio, C; Lhomme, S; Chiabrando, J; Saune, K; Peron, J M; Kamar, N; Evrard, S; de Valk, H; Cintas, P; Izopet, J; study , H E V

Acute hepatitis E in French patients and neurological manifestations Journal Article

J Infect, 77 (3), pp. 220-226, 2018, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Mansuy, J M; Lhomme, S; Cazabat, M; Pasquier, C; Martin-Blondel, G; Izopet, J

Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR Journal Article

Diagn Microbiol Infect Dis, 92 (4), pp. 284-287, 2018, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Raymond, S; Delaugerre, C; Nicot, F; Assoumou, L; Lancar, R; Beniguel, L; Izopet, J; study , Anrs Optimal

Accurate quantification of CXCR4-using HIV-1 variants by Illumina deep-sequencing Journal Article

AIDS, 32 (16), pp. 2429-2431, 2018, ISSN: 1473-5571 (Electronic) 0269-9370 (Linking).

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Jadoul, M; Berenguer, M C; Doss, W; Fabrizi, F; Izopet, J; Jha, V; Kamar, N; Kasiske, B L; Lai, C L; Morales, J M; Patel, P R; Pol, S; Silva, M O; Balk, E M; Gordon, C E; Earley, A; Di, M; Martin, P

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management Journal Article

Kidney Int, 94 (4), pp. 663-673, 2018, ISSN: 1523-1755 (Electronic) 0085-2538 (Linking).

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Abravanel, F; Lacipiere, A; Lhomme, S; Dubois, M; Minier, L; Peron, J M; Alric, L; Kamar, N; Izopet, J

Performance of a commercial assay for detecting and quantifying HEV RNA in faeces Journal Article

J Clin Virol, 109 , pp. 1-5, 2018, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Capelli, N; Marion, O; Dubois, M; Allart, S; Bertrand-Michel, J; Lhomme, S; Abravanel, F; Izopet, J; Chapuy-Regaud, S

Vectorial Release of Hepatitis E Virus in Polarized Human Hepatocytes Journal Article

J Virol, 2018, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Dimeglio, C; Beau, F; Broult, J; Gouy, P; Izopet, J; Lastere, S; Abravanel, F

Hepatitis E prevalence in French Polynesian blood donors Journal Article

PLoS One, 13 (12), pp. e0208934, 2018, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Dimeglio, C; Raymond, S; Nicot, F; Jeanne, N; Carcenac, R; Lefebvre, C; Izopet, J; French National Agency for Research on, Aids ; Viral Hepatitis, Resistance Study Group A C

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen Journal Article

J Antimicrob Chemother, 2018, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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2017

Lhomme, S; Bardiaux, L; Abravanel, F; Gallian, P; Kamar, N; Izopet, J

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France Journal Article

Emerg Infect Dis, 23 (2), pp. 353-356, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Hocine, H R; Costa, H E; Dam, N; Giustiniani, J; Palacios, I; Loiseau, P; Bensussan, A; Borlado, L R; Charron, D; Suberbielle, C; Jabrane-Ferrat, N; Al-Daccak, R

Minimizing the risk of allo-sensitization to optimize the benefit of allogeneic cardiac-derived stem/progenitor cells Journal Article

Sci Rep, 7 , pp. 41125, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Dam, N; Hocine, H R; Palacios, I; DelaRosa, O; Menta, R; Charron, D; Bensussan, A; El Costa, H; Jabrane-Ferrat, N; Dalemans, W; Lombardo, E; Al-Daccak, R

Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair Journal Article

Front Immunol, 8 , pp. 1413, 2017, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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Srivastava, R; Khan, A A; Chilukuri, S; Syed, S A; Tran, T T; Furness, J; Bahraoui, E; BenMohamed, L

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8(+) TEM and CD8(+) TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease Journal Article

J Virol, 91 (14), 2017, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Serrero, M; Planes, R; Bahraoui, E

PKC-delta isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-kappaB and CXCL8 production Journal Article

Sci Rep, 7 (1), pp. 2384, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Donnelly, M C; Imlach, S N; Abravanel, F; Ramalingam, S; Johannessen, I; Petrik, J; Fraser, A R; Campbell, J D; Bramley, P; Dalton, H R; Hayes, P C; Kamar, N; Simpson, K J

Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient Journal Article

Gastroenterology, 152 (1), pp. 300-301, 2017, ISSN: 1528-0012 (Electronic) 0016-5085 (Linking).

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Abravanel, F; Lhomme, S; Fougere, M; Saune, K; Alvarez, M; Peron, J M; Delobel, P; Izopet, J

HEV infection in French HIV-infected patients Journal Article

J Infect, 74 (3), pp. 310-313, 2017, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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Raymond, S; Nicot, F; Jeanne, N; Delfour, O; Carcenac, R; Lefebvre, C; Cazabat, M; Saune, K; Delobel, P; Izopet, J

Performance comparison of next-generation sequencing platforms for determining HIV-1 coreceptor use Journal Article

Sci Rep, 7 , pp. 42215, 2017, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Sayed, I M; Foquet, L; Verhoye, L; Abravanel, F; Farhoudi, A; Leroux-Roels, G; Izopet, J; Meuleman, P

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma Journal Article

Antiviral Res, 141 , pp. 150-154, 2017, ISSN: 1872-9096 (Electronic) 0166-3542 (Linking).

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Abravanel, F; Goutagny, N; Perret, C; Lhomme, S; Vischi, F; Aversenq, A; Chapel, A; Dehainault, N; Piga, N; Dupret-Carruel, J; Izopet, J

Evaluation of two VIDAS ((R))prototypes for detecting anti-HEV IgG Journal Article

J Clin Virol, 89 , pp. 46-50, 2017, ISSN: 1873-5967 (Electronic) 1386-6532 (Linking).

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Mansuy, J M; Mengelle, C; Pasquier, C; Chapuy-Regaud, S; Delobel, P; Martin-Blondel, G; Izopet, J

Zika Virus Infection and Prolonged Viremia in Whole-Blood Specimens Journal Article

Emerg Infect Dis, 23 (5), pp. 863-865, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Pasquier, C; Saune, K; Raymond, S; Boisneau, J; Courtade, M; Izopet, J

Comparison of Cobas(R) HPV and Anyplex II HPV28 assays for detecting and genotyping human papillomavirus Journal Article

Diagn Microbiol Infect Dis, 87 (1), pp. 25-27, 2017, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Kamar, N; Wang, W; Dalton, H R; Pan, Q

Direct-acting antiviral therapy for hepatitis E virus? Journal Article

Lancet Gastroenterol Hepatol, 2 (3), pp. 154-155, 2017, ISSN: 2468-1253 (Electronic).

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Velay, A; Kack-Kack, W; Abravanel, F; Lhomme, S; Leyendecker, P; Kremer, L; Chamouard, P; Izopet, J; Fafi-Kremer, S; Barth, H

Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient Journal Article

J Neurovirol, 23 (4), pp. 615-620, 2017, ISSN: 1538-2443 (Electronic) 1355-0284 (Linking).

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Chapuy-Regaud, S; Dubois, M; Plisson-Chastang, C; Bonnefois, T; Lhomme, S; Bertrand-Michel, J; You, B; Simoneau, S; Gleizes, P E; Flan, B; Abravanel, F; Izopet, J

Characterization of the lipid envelope of exosome encapsulated HEV particles protected from the immune response Journal Article

Biochimie, 141 , pp. 70-79, 2017, ISSN: 1638-6183 (Electronic) 0300-9084 (Linking).

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Dorr, G; Del Bello, A; Abravanel, F; Marion, O; Cointault, O; Ribes, D; Lavayssiere, L; Esposito, L; Nogier, M B; Hebral, A L; Saune, K; Izopet, J; Kamar, N

Malignancies in hepatitis C virus-positive and -negative kidney transplant recipients: A case-controlled study Journal Article

Transpl Infect Dis, 19 (4), 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Yin, X; Li, X; Ambardekar, C; Hu, Z; Lhomme, S; Feng, Z

Hepatitis E virus persists in the presence of a type III interferon response Journal Article

PLoS Pathog, 13 (5), pp. e1006417, 2017, ISSN: 1553-7374 (Electronic) 1553-7366 (Linking).

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Metsu, D; Toutain, P L; Chatelut, E; Delobel, P; Gandia, P

Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle? Journal Article

J Antimicrob Chemother, 72 (9), pp. 2407-2409, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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Abravanel, F; Lhomme, S; El Costa, H; Schvartz, B; Peron, J M; Kamar, N; Izopet, J

Rabbit Hepatitis E Virus Infections in Humans, France Journal Article

Emerg Infect Dis, 23 (7), pp. 1191-1193, 2017, ISSN: 1080-6059 (Electronic) 1080-6040 (Linking).

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Moulin, M; Alguacil, J; Gu, S; Mehtougui, A; Adams, E J; Peyrottes, S; Champagne, E

Vgamma9Vdelta2 T cell activation by strongly agonistic nucleotidic phosphoantigens Journal Article

Cell Mol Life Sci, 74 (23), pp. 4353-4367, 2017, ISSN: 1420-9071 (Electronic) 1420-682X (Linking).

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Izopet, J; Lhomme, S; Chapuy-Regaud, S; Mansuy, J M; Kamar, N; Abravanel, F

HEV and transfusion-recipient risk Journal Article

Transfus Clin Biol, 24 (3), pp. 176-181, 2017, ISSN: 1953-8022 (Electronic) 1246-7820 (Linking).

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Dalton, H R; van Eijk, J J J; Cintas, P; Madden, R G; Jones, C; Webb, G W; Norton, B; Pique, J; Lutgens, S; Devooght-Johnson, N; Woolson, K; Baker, J; Saunders, M; Househam, L; Griffiths, J; Abravanel, F; Izopet, J; Kamar, N; van Alfen, N; van Engelen, B G M; Hunter, J G; van der Eijk, A A; Bendall, R P; McLean, B N; Jacobs, B C

Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study Journal Article

J Hepatol, 67 (5), pp. 925-932, 2017, ISSN: 1600-0641 (Electronic) 0168-8278 (Linking).

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Joguet, G; Mansuy, J M; Matusali, G; Hamdi, S; Walschaerts, M; Pavili, L; Guyomard, S; Prisant, N; Lamarre, P; Dejucq-Rainsford, N; Pasquier, C; Bujan, L

Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Journal Article

Lancet Infect Dis, 17 (11), pp. 1200-1208, 2017, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Pasquier, C; Walschaerts, M; Raymond, S; Moinard, N; Saune, K; Daudin, M; Izopet, J; Bujan, L

Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy Journal Article

Basic Clin Androl, 27 , pp. 17, 2017, ISSN: 2051-4190 (Print) 2051-4190 (Linking).

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Barrague, H; Condat, B; Petitdidier, N; Champagne, E; Renou, C; Izopet, J; Abravanel, F

Chronic hepatitis E virus infection in a cirrhotic patient: A case report Journal Article

Medicine (Baltimore), 96 (39), pp. e7915, 2017, ISSN: 1536-5964 (Electronic) 0025-7974 (Linking).

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Belliere, J; Abravanel, F; Nogier, M B; Martinez, S; Cintas, P; Lhomme, S; Lavayssiere, L; Cointault, O; Faguer, S; Izopet, J; Kamar, N

Transfusion-acquired hepatitis E infection misdiagnosed as severe critical illness polyneuromyopathy in a heart transplant patient Journal Article

Transpl Infect Dis, 19 (6), 2017, ISSN: 1399-3062 (Electronic) 1398-2273 (Linking).

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Kamar, N; Izopet, J; Pavio, N; Aggarwal, R; Labrique, A; Wedemeyer, H; Dalton, H R

Hepatitis E virus infection Journal Article

Nat Rev Dis Primers, 3 , pp. 17086, 2017, ISSN: 2056-676X (Electronic) 2056-676X (Linking).

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de Truchis, P; Assoumou, L; Landman, R; Mathez, D; Le Du, D; Bellet, J; Amat, K; Katlama, C; Gras, G; Bouchaud, O; Duracinsky, M; Abe, E; Alvarez, J C; Izopet, J; Saillard, J; Melchior, J C; Leibowitch, J; Costagliola, D; Girard, P M; Perronne, C; Group, Anrs Study D

Four-days-a-week antiretroviral maintenance therapy in virologically controlled HIV-1-infected adults: the ANRS 162-4D trial Journal Article

J Antimicrob Chemother, 2017, ISSN: 1460-2091 (Electronic) 0305-7453 (Linking).

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2016

Abravanel, F; Barrague, H; Dorr, G; Saune, K; Peron, J M; Alric, L; Kamar, N; Izopet, J; Champagne, E

Conventional and innate lymphocytes response at the acute phase of HEV infection in transplanted patients Journal Article

J Infect, 72 (6), pp. 723-730, 2016, ISSN: 1532-2742 (Electronic) 0163-4453 (Linking).

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El Costa, H; Gouilly, J; Mansuy, J M; Chen, Q; Levy, C; Cartron, G; Veas, F; Al-Daccak, R; Izopet, J; Jabrane-Ferrat, N

ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy Journal Article

Sci Rep, 6 , pp. 35296, 2016, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Gasser, R; Hamoudi, M; Pellicciotta, M; Zhou, Z; Visdeloup, C; Colin, P; Braibant, M; Lagane, B; Negroni, M

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions Journal Article

Retrovirology, 13 (1), pp. 50, 2016, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Loiseau, C; Requena, M; Mavigner, M; Cazabat, M; Carrere, N; Suc, B; Barange, K; Alric, L; Marchou, B; Massip, P; Izopet, J; Delobel, P

CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals Journal Article

Mucosal Immunol, 9 (5), pp. 1137-50, 2016, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

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Mansuy, J M; Dutertre, M; Mengelle, C; Fourcade, C; Marchou, B; Delobel, P; Izopet, J; Martin-Blondel, G

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Journal Article

Lancet Infect Dis, 16 (4), pp. 405, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Benureau, Y; Colin, P; Staropoli, I; Gonzalez, N; Garcia-Perez, J; Alcami, J; Arenzana-Seisdedos, F; Lagane, B

Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins Journal Article

J Virol Methods, 236 , pp. 184-95, 2016, ISSN: 1879-0984 (Electronic) 0166-0934 (Linking).

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Planes, R; Ben Haij, N; Leghmari, K; Serrero, M; BenMohamed, L; Bahraoui, E

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes Journal Article

J Virol, 90 (13), pp. 5886-5898, 2016, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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2015

Garcia-Perez, J; Staropoli, I; Azoulay, S; Heinrich, J T; Cascajero, A; Colin, P; Lortat-Jacob, H; Arenzana-Seisdedos, F; Alcami, J; Kellenberger, E; Lagane, B

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity Journal Article

Retrovirology, 12 , pp. 50, 2015, ISSN: 1742-4690 (Electronic) 1742-4690 (Linking).

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Jeanne, N; Saliou, A; Carcenac, R; Lefebvre, C; Dubois, M; Cazabat, M; Nicot, F; Loiseau, C; Raymond, S; Izopet, J; Delobel, P

Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism Journal Article

Sci Rep, 5 , pp. 16944, 2015, ISSN: 2045-2322 (Electronic) 2045-2322 (Linking).

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Lhomme, S; Kamar, N; Nicot, F; Ducos, J; Bismuth, M; Garrigue, V; Petitjean-Lecherbonnier, J; Ollivier, I; Alessandri-Gradt, E; Goria, O; Barth, H; Perrin, P; Saune, K; Dubois, M; Carcenac, R; Lefebvre, C; Jeanne, N; Abravanel, F; Izopet, J

Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy Journal Article

Antimicrob Agents Chemother, 60 (3), pp. 1608-14, 2015, ISSN: 1098-6596 (Electronic) 0066-4804 (Linking).

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Siewiera, J; Gouilly, J; Hocine, H R; Cartron, G; Levy, C; Al-Daccak, R; Jabrane-Ferrat, N

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes Journal Article

Nat Commun, 6 , pp. 10183, 2015, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Ben Haij, N; Planes, R; Leghmari, K; Serrero, M; Delobel, P; Izopet, J; BenMohamed, L; Bahraoui, E

HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-kappaB Pathway Journal Article

PLoS One, 10 (6), pp. e0129425, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Ainaoui, N; Hantelys, F; Renaud-Gabardos, E; Bunel, M; Lopez, F; Pujol, F; Planes, R; Bahraoui, E; Pichereaux, C; Burlet-Schiltz, O; Parini, A; Garmy-Susini, B; Prats, A C

Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation Journal Article

PLoS One, 10 (9), pp. e0136466, 2015, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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2014

Kamar, N; Izopet, J; Tripon, S; Bismuth, M; Hillaire, S; Dumortier, J; Radenne, S; Coilly, A; Garrigue, V; D'Alteroche, L; Buchler, M; Couzi, L; Lebray, P; Dharancy, S; Minello, A; Hourmant, M; Roque-Afonso, A M; Abravanel, F; Pol, S; Rostaing, L; Mallet, V

Ribavirin for chronic hepatitis E virus infection in transplant recipients Journal Article

N Engl J Med, 370 (12), pp. 1111-20, 2014, ISSN: 1533-4406 (Electronic) 0028-4793 (Linking).

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Jabrane-Ferrat, N; Siewiera, J

The up side of decidual natural killer cells: new developments in immunology of pregnancy Journal Article

Immunology, 141 (4), pp. 490-7, 2014, ISSN: 1365-2567 (Electronic) 0019-2805 (Linking).

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Lauden, L; Siewiera, J; Boukouaci, W; Ramgolam, K; Mourah, S; Lebbe, C; Charron, D; Aoudjit, F; Jabrane-Ferrat, N; Al-Daccak, R

TGF-beta-induced (TGFBI) protein in melanoma: a signature of high metastatic potential Journal Article

J Invest Dermatol, 134 (6), pp. 1675-1685, 2014, ISSN: 1523-1747 (Electronic) 0022-202X (Linking).

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Boukouaci, W; Lauden, L; Siewiera, J; Dam, N; Hocine, H R; Khaznadar, Z; Tamouza, R; Borlado, L R; Charron, D; Jabrane-Ferrat, N; Al-Daccak, R

Natural killer cell crosstalk with allogeneic human cardiac-derived stem/progenitor cells controls persistence Journal Article

Cardiovasc Res, 104 (2), pp. 290-302, 2014, ISSN: 1755-3245 (Electronic) 0008-6363 (Linking).

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Planes, R; BenMohamed, L; Leghmari, K; Delobel, P; Izopet, J; Bahraoui, E

HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms Journal Article

J Virol, 88 (12), pp. 6672-89, 2014, ISSN: 1098-5514 (Electronic) 0022-538X (Linking).

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Bahraoui, E; Briant, L; Chazal, N

E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein Journal Article

Virol J, 11 , pp. 214, 2014, ISSN: 1743-422X (Electronic) 1743-422X (Linking).

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Social impact

Knowledge of the biology of RNA viruses and pathophysiological mechanisms.

Our research generates fundamental knowledge about chronic viral infections (HIV and HEV) and emerging infection (ZIKV), and clinical applications to combat these viruses whose pathophysiology remains unclear. Our links with the clinical departments of Toulouse University Hospital, with the technical platform of the CPTP and several international collaborations ensure the optimal development of original themes.

Teaching commitment

Our team members are committed to the teaching of students in the faculties of Medicine and Pharmacy; we also welcome Master and PhD students from both France and abroad to work and study in our laboratory.

Alumni

H. Barragué (PhD student)
R. Gasser (post-doc)
J. Gouilly (PhD student)

INSERM

INSERM

CNRS

CNRS

ANRS

ANRS

Sidaction

Sidaction

Hôpitaux de Toulouse

Hôpitaux de Toulouse

Agence de la biomédecine

Agence de la biomédecine

UT3

UT3