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Study antigen presentation to T cells during T. gondii and Plasmodium infections

Santi-Rocca J, Blanchard N.
Membrane trafficking and remodeling at the host-parasite interface
Curr Opin Microbiol. 2017 (in press)

Draheim M, Wlodarczyk MF, Crozat K, Saliou JM, Alayi TD, Tomavo S, Hassan A, Salvioni A, Demarta-Gatsi C, Sidney J, Sette A, Dalod M, Berry A, Silvie O, Blanchard N.
Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells.
EMBO Mol Med. 2017 Sep 21. pii: e201708123. doi: 10.15252/emmm.201708123.

Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N*, Blanchard N*. (*=co-senior)
Protease-Activated Receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.
Parasite Immunol. 2017 Sep 7. doi: 10.1111/pim.12489.

Buaillon C, Guerrero NA, Cebrian I, Blanié S, Lopez J, Bassot E, Vasseur V, Santi-Rocca J, Blanchard N
MHC I presentation of Toxoplasma gondii immunodominant antigen does not require Sec22b and is regulated by antigen orientation at the vacuole membrane
Eur J Immunol 2017 May 15. doi: 10.1002/eji.201646859.

Cebrian I, Croce C, Guerrero NA, Blanchard N* , Mayorga LS*. (*=co-senior)
Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells.
EMBO Rep. 2016 Dec;17(12):1753-1765.

Chu HH, Chan SW, Gosling JP, Blanchard N, Tsitsiklis A, Lythe G, Shastri N, Molina-París C, Robey EA.
Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.
Immunity. 2016 Jul 19;45(1):159-71. doi: 10.1016/j.immuni.2016.06.013.

Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N
Intravacuolar membranes regulate CD8 T cell recognition of membrane-bound Toxoplasma gondii protective antigen.
Cell Rep 2015 Nov 23. pii: S2211-1247(15)01288-7. doi: 10.1016/j.celrep.2015.11.001.

Joulia R, Gaudenzio N, Rodrigues M, Lopez J, Blanchard N, Valitutti S, Espinosa E
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.
Nat Commun. 2015 Jan 28;6:6174. doi: 10.1038/ncomms7174

Blanchard N, Dunay IR, Schlüter D
Persistence of Toxoplasma gondii in the central nervous system: a fine tuned balance between the parasite, the brain and the immune system (Review)
Parasite Immunol 2015 Mar;37(3):150-8. doi: 10.1111/pim.12173. [Review]

Feliu V, Vasseur V, Grover HS, Chu HH, Brown MJ, Wang J, Boyle JP, Robey EA, Shastri N, Blanchard N
Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite.
PLoS Pathog. 2013 Jun;9(6):e1003449

Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A
Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells.
Cell 2011 Dec 9, 147(6), 1355–1368


Analyse the sreading pattern and molecular mechanisms of malaria parasite chemoresistance

Menard S, Tchoufack JN, Maffo CN, Nsango SE, Iriart X, Abate L, Tsapi MT, Awono-Ambéné PH, Abega Mekongo FA, Morlais I, Berry A.
Insight into k13-propeller gene polymorphism and ex vivo DHA-response profiles from Cameroonian isolates.
Malar J. 2016 Nov 26;15(1):572.

Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.

Ménard S, Ben Haddou T, Ramadani AP, Ariey F, Iriart X, Beghain J, Bouchier C, Witkowski B, Berry A, Mercereau-Puijalon O, Benoit-Vical F.
Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure.
Emerg Infect Dis. 2015 Oct;21(10):1733-41. doi: 10.3201/eid2110.150682.

Chauvin P, Menard S, Iriart X, Nsango SE, Tchioffo MT, Abate L, Awono-Ambéné PH, Morlais I, Berry A.
Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in pregnant women in Yaoundé, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles.
J Antimicrob Chemother. 2015 Sep;70(9):2566-71. doi: 10.1093/jac/dkv160. Epub 2015 Jun 16.

Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D.
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18.

Tchioffo MT, Boissière A, Churcher TS, Abate L, Gimonneau G, Nsango SE, Awono-Ambéné PH, Christen R, Berry A, Morlais I.
Modulation of Malaria Infection in Anopheles gambiae Mosquitoes Exposed to Natural Midgut Bacteria.
PLoS One. 2013 Dec 6;8(12):e81663. doi: 10.1371/journal.pone.0081663.

Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D.
Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
Antimicrob Agents Chemother. 2013 Feb;57(2):914-23. doi: 10.1128/AAC.01868-12. Epub 2012 Dec 3.

Menard S, Morlais I, Tahar R, Sayang C, Mayengue PI, Iriart X, Benoit-Vical F, Lemen B, Magnaval JF, Awono-Ambene P, Basco LK, Berry A.
Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future.
Malar J. 2012 Apr 12;11:113. doi: 10.1186/1475-2875-11-113.

 

Last updated September 27, 2017


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm University of Toulouse Université Toulouse III - Paul Sabatier