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16 déc.

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Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L & Love PE
Themis2 lowers the threshold for B cell activation during positive selection.
Nat Immunol. 2017, Feb.

Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ.
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Nat Immunol. 2016, Dec.

Zvezdova E, Mikolajczak J, Garreau A, Marcelin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R.
Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Sci Signal. 2016, May.

Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andreoletti O, Dejean AS, Lesourne R, Fournié GJ, Saoudi A.
An epistatic interaction between Themis1 and Vav1 modulates regulatory T cell function and inflammatory bowel disease development.
J Immunol. 2015 Aug 15;195(4):1608-16. doi: 10.4049/jimmunol.1402562.

Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE.
TCR ITAM multiplicity is required for the generation of follicular helper T-cells.
Nat Commun. 2015, May.

Hwang S, Song KD, Lesourne R, Lee J, Pinkhasov J, Li L, El-Khoury D, Love PE.
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.
J Exp Med. 2012, Sep.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049.

Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE.
Themis1, a T cell-specific protein important for late thymocyte development.
Nat Immunol. 2009 Aug;10(8):840-7.


Date de mise à jour 2 mars 2017


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier