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18 déc.

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Molecular and Physiological analysis of T cell signaling

Head: Renaud Lesourne















A critical component of the immunological response to foreign protein is the activation of T lymphocytes. T-cell receptor (TCR) recognition of peptide loaded-histocompatibility molecules (MHC) provides antigen specificity and initiates the required steps for T-cell activation and differentiation into T cell subsets with specific and adapted immune function. The recognition of peptide-MHC complexes by TCRs triggers the activation of a complex network of intracellular signaling pathways. The quality, the duration and the strength of these signals determine the outcome of T cell responses and is therefore critical for 1) the discrimination between self and non self antigens, 2) the generation and expansion of the appropriate functional T cell subsets, 3) the control of pathological disorders

The aim of our research is to identify new molecular mechanisms involved in T cell signaling and to investigate their functional consequences on T cell responses during physiological or pathophysiological processes such as autoimmune and inflammatory diseases. We use proteomic analysis to identify new actors of T cell signaling and genetically engineered murine models to study the function of these proteins in the development of immune-mediated disorders.




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Signaling and microtubule dynamics in T cells



 


Last updated January 10, 2017


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm University of Toulouse Université Toulouse III - Paul Sabatier