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Différences liées au sexe dans l’immunité : mécanismes et physiopathologie

Head : J.C. Guéry


 








The nature and strength of the immune response differ between women and men, resulting in sex-based differences in the prevalence, manifestations and outcome of autoimmune and infectious diseases. While women are able to mount a more vigorous immune response to infections, they also suffer more from autoimmune diseases and inflammation-induced tissue damages. Growing data indicate that common biological pathways leading to inflammation and immune activation are involved in the pathophysiology of autoimmune and infectious diseases, and that these pathways are regulated by sex-linked factors, including sex hormones and sex-chromosome loci. Our team is interested in understanding the mechanisms by which sex-specific factors regulate the immune responses. Our current research objectives focus on three main areas:



Protective effect of estrogens on CNS autoimmunity




 

Understanding the Sex bias in Innate immunity




 

Infectious and allergic respiratory diseases




 


Date de mise à jour 21 avril 2016


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier