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Decipher how malaria blood stage infection modulates immune cell functions, in particular dendritic cells and CD4 T cells (N. Blanchard)

Cerebral Malaria is a severe complication of P. falciparum malaria, characterized by brain microhemorrhages, edema and coma/death if not treated. Cerebral malaria is associated with pRBC sequestration in microcapillaries and in an experimental rodent models, CD8 T cells are the major effectors of endothelial damage. CD4 T cells are also essential for the disease develoment but the parasite antigens presented by dendritic cells (DC) and recognized by CD4 T cells during the disease are unknown. Futhermore, why different lines of rodent-adapted Plasmodium berghei induce different disease outcomes remains poorly understood. Our goal is to elucidate how pRBC modulate immune cells, such as DC and T cells, resulting in various degrees of immunopathology.

We are characterizing CD4 T cell epitopes and the impact of DC subsets on CD4 T cell differentiation during blood stage malaria (Marion Draheim, PhD student, Draheim et al, EMBO Mol Med 2017)

Mouse red blood cells parasitized with Plamodium berghei parasites.

Last updated September 27, 2017

Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm University of Toulouse Université Toulouse III - Paul Sabatier