22 mars

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Antigen Presenting Cells and CD4 T cell responses

Heads : S. Guerder & N. Fazilleau


The main focus of our team is to examine how cellular interactions between antigen-presenting cells and T Helper cells impact immune responses in physiological or pathological contexts. We thus examine the mechanisms that regulate dendritic cell (DC) function to either induce T cell tolerance in autoimmune context or appropriate immune response for vaccine development or for the development of antitumor responses. We also examine how antigen-presenting cell-derived factors may contribute to the development of effector and memory T cells with a particular focus on the cognate regulators of B cell immunity, the Follicular Helper T (Tfh) cells.

Dendritic cells in central tolerance and autoimmunity


Physiology, anatomy and regulation of T-dependent B cell responses


Development of anti-tumor T cell responses


Last updated January 12, 2016

Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm University of Toulouse Université Toulouse III - Paul Sabatier