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22 déc.

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CPTP Présentation

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Directeur : Roland LIBLAU.
Directrices-Adjointes :
Marie-Paule ROTH et Nathalie VERGNOLLE.

 Le Centre de Physiopathologie de Toulouse-Purpan (CPTP) a été l'un des premiers Centres de Recherche biomédicale créés par l'Inserm en 2002. la suite...

Dernières publications


Boukouaci W, Lauden L, Siewiera J, Dam N, Hocine HR, Khaznadar Z, Tamouza R, Borlado LR, Charron D, Jabrane-Ferrat N, Al-Daccak R.
Natural killer cell crosstalk with allogeneic human cardiac-derived stem/progenitor cells controls persistence.
Cardiovasc Res. 2014 Nov 1;104(2):290-302. doi: 10.1093/cvr/cvu208. Epub 2014 Sep 11.

Szelechowski M, Bétourné A, Monnet Y, Ferré CA, Thouard A, Foret C, Peyrin JM, Hunot S, Gonzalez-Dunia D.
A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
Nat Commun. 2014 Oct 21;5:5181. doi: 10.1038/ncomms6181.

Laird ME, Mohsen A, Duffy D, Mamdouh R, LeFouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky JM, Hézode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A.
Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.
J Hepatol. 2014 Oct;61(4):770-6. doi: 10.1016/j.jhep.2014.05.040. Epub 2014 Jun 4.

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB.
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.

Schuh C, Wimmer I, Hametner S, Haider L, Van Dam AM, Liblau RS, Smith KJ, Probert L, Binder CJ, Bauer J, Bradl M, Mahad D, Lassmann H.
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Acta Neuropathol. 2014 Aug;128(2):247-66. doi: 10.1007/s00401-014-1263-5. Epub 2014 Mar 13.

Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.
Targeting PI3K activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29

Kamar N, Izopet J.
Does chronic hepatitis E virus infection exist in immunocompetent patients?
Hepatology. 2014 Jul;60(1):427. doi: 10.1002/hep.26927. Epub 2014 May 27.

Kamar N, Mallet V, Izopet J.
Ribavirin for chronic hepatitis E virus infection.
N Engl J Med. 2014 Jun 19;370(25):2447-8. doi: 10.1056/NEJMc1405191.

Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.

Furio L, de Veer S, Jaillet M, Briot A, Robin A, Deraison C, Hovnanian A.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
J Exp Med. 2014 Mar 10;211(3):499-513. doi: 10.1084/jem.20131797. Epub 2014 Feb 17.

Kamar N, Izopet J, Tripon S, Bismuth M, Hillaire S, Dumortier J, Radenne S, Coilly A, Garrigue V, D'Alteroche L, Buchler M, Couzi L, Lebray P, Dharancy S, Minello A, Hourmant M, Roque-Afonso AM, Abravanel F, Pol S, Rostaing L, Mallet V.
Ribavirin for chronic hepatitis E virus infection in transplant recipients.
N Engl J Med. 2014 Mar 20;370(12):1111-20. doi: 10.1056/NEJMoa1215246.

Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.

Kamar N, Dalton HR, Abravanel F, Izopet J.
Hepatitis E virus infection.
Clin Microbiol Rev. 2014 Jan;27(1):116-38. doi: 10.1128/CMR.00057-13.

Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D.
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18.

Robert V, Triffaux E, Paulet PE, Guéry JC, Pelletier L, Savignac M.
Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions.
J Allergy Clin Immunol. 2014 Apr;133(4):1175-83. doi: 10.1016/j.jaci.2013.10.038. Epub 2013 Dec 22.

Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP.
Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin.
Hepatology. 2014 Feb;59(2):683-94. doi: 10.1002/hep.26648. Epub 2013 Dec 16.

Martin P, Marcq I, Magistro G, Penary M, Garcie C, Payros D, Boury M, Olier M, Nougayrede JP, Audebert M, Chalut C, Schubert S and Oswald E.
Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.
PLoS Pathog. 2013;9(7):e1003437. doi: 10.1371/journal.ppat.1003437. Epub 2013 Jul 11.

Feliu V, Vasseur V, Grover HS, Chu HH, Brown MJ, Wang J, Boyle JP, Robey EA, Shastri N, Blanchard N.
Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite.
PLoS Pathog. 2013;9(6):e1003449. doi: 10.1371/journal.ppat.1003449. Epub 2013 Jun 20.

Seillet C, Rouquié N, Foulon E, Douin-Echinard V, Krust A, Chambon P, Arnal JF, Guéry JC, Laffont S.
Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor.
J Immunol. 2013 Jun 1;190(11):5459-70. doi: 10.4049/jimmunol.1203312. Epub 2013 Apr 26.

Gaudenzio N, Laurent C, Valitutti S, Espinosa E.
Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype.
J Allergy Clin Immunol. 2013 May;131(5):1400-7.e11. doi: 10.1016/j.jaci.2013.01.029. Epub 2013 Mar 19.

Pasquet L, Douet JY, Sparwasser T, Romagnoli P, van Meerwijk JP.
Long term prevention of chronic allograft rejection by regulatory T cell immunotherapy involves host Foxp3-expressing T cells.
Blood. 2013 May 23;121(21):4303-10. doi: 10.1182/blood-2012-08-452037. Epub 2013 Apr 11.

Bertrand F, Müller S, Roh KH, Laurent C, Dupré L, Valitutti S.
An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6073-8. doi: 10.1073/pnas.1218640110. Epub 2013 Mar 27.

Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, Jabrane-Ferrat N.
Human cytomegalovirus infection elicits new decidual natural killer cell effector functions.
PLoS Pathog. 2013;9(4):e1003257. doi: 10.1371/journal.ppat.1003257. Epub 2013 Apr 4.

Liblau RS, Gonzalez-Dunia D, Wiendl H, Zipp F.
Neurons as targets for T cells in the nervous system.
Trends Neurosci. 2013 Jun;36(6):315-24. doi: 10.1016/j.tins.2013.01.008. Epub 2013 Mar 13

Evénements

Séminaires Séminaire le 15/01/2015 à 11h00

présentée par : Dr. Janine Coombes


Salle P. Druet, CPTP Bât A rdc, CHU Purpan


Team

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Annuaire

Localisation du CPTP

CPTP
INSERM UMR 1043 / CNRS UMR 5282
Université Toulouse III
CHU Purpan
BP 3028
31024 Toulouse CEDEX 03
Tél. : 05 62 74 45 45
Fax : 05 62 74 45 58

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Date de mise à jour 5 décembre 2014


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier