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25 mai

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CPTP Présentation


Directeur : Roland LIBLAU.
Directeurs Adjoints : Paola ROMAGNOLI & Jacques IZOPET

Le Centre de Physiopathologie de Toulouse-Purpan (CPTP) a été l'un des premiers Centres de Recherche biomédicale créés par l'Inserm en 2002... la suite...

Dernières publications



Laffont S, Blanquart E, Savignac M, Cénac C, Laverny G, Metzger D, Girard JP, Belz GT, Pelletier L, Seillet C, Guéry JC.
Androgen signaling negatively controls group 2 innate lymphoid cells.
J Exp Med. 2017 May 8. pii: jem.20161807. doi: 10.1084/jem.20161807. [Epub ahead of print]

Duguet F, Locard-Paulet M, Marcellin M, Chaoui K, Bernard I, Andreoletti O, Lesourne R, Burlet-Schiltz O, Gonzalez de Peredo A, Saoudi A.
Proteomic analysis of regulatory T cells reveals the importance of Themis1 in the control of their suppressive function.
Mol Cell Proteomics. 2017 Apr 3. pii: mcp.M116.062745. doi: 10.1074/mcp.M116.062745. [Epub ahead of print]

Joulia R, Mailhol C, Valitutti S, Didier A, Espinosa E.
Direct monitoring of basophil degranulation by using avidin-based probes.
J Allergy Clin Immunol. 2017 Apr 19. pii: S0091-6749(17)30658-9. doi: 10.1016/j.jaci.2017.03.030. [Epub ahead of print]

Hartmann FJ, Bernard-Valnet R, Quériault C, Mrdjen D, Weber LM, Galli E, Krieg C, Robinson MD, Nguyen XH, Dauvilliers Y, Liblau RS, Becher B.
High-dimensional single-cell analysis reveals the immune signature of narcolepsy.
J Exp Med. 2016 Nov 14;213(12):2621-2633. Epub 2016 Nov 7.

Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick SM, Saoudi A, Dejean AS.
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.
Immunity. 2016 Oct 18;45(4):774-787. doi: 10.1016/j.immuni.2016.09.010. Epub 2016 Oct 11.

Mansuy JM, Suberbielle E, Chapuy-Regaud S, Mengelle C, Bujan L, Marchou B, Delobel P, Gonzalez-Dunia D, Malnou CE, Izopet J, Martin-Blondel G.
Zika virus in semen and spermatozoa.
Lancet Infect Dis. 2016 Oct;16(10):1106-7. doi: 10.1016/S1473-3099(16)30336-X. Epub 2016 Sep 19.

Blouin CM, Hamon Y, Gonnord P, Boularan C, Kagan J, Viaris de Lesegno C, Ruez R, Mailfert S, Bertaux N, Loew D, Wunder C, Johannes L, Vogt G, Contreras FX, Marguet D, Casanova JL, Galès C, He HT, Lamaze C.
Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.
Cell. 2016 Aug 11;166(4):920-34. doi: 10.1016/j.cell.2016.07.003. Epub 2016 Aug 4.

Menard S, Tchoufack JN, Maffo CN, Nsango SE, Iriart X, Abate L, Tsapi MT, Awono-Ambéné PH, Abega Mekongo FA, Morlais I, Berry A.
Insight into k13-propeller gene polymorphism and ex vivo DHA-response profiles from Cameroonian isolates.
Malar J. 2016 Nov 26;15(1):572.

Mansuy JM, Dutertre M, Mengelle C, Fourcade C, Marchou B, Delobel P, Izopet J, Martin-Blondel G.
Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?
Lancet Infect Dis. 2016 Apr;16(4):405. doi: 10.1016/S1473-3099(16)00138-9. Epub 2016 Mar 4.

Decque A, Joffre O, Magalhaes JG, Cossec JC, Blecher-Gonen R, Lapaquette P, Silvin A, Manel N, Joubert PE, Seeler JS, Albert ML, Amit I, Amigorena S, Dejean A.
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.
Nat Immunol. 2016 Feb;17(2):140-9. doi: 10.1038/ni.3342. Epub 2015 Dec 14.

Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS.
CCR5 blockade for neuro-inflammatory diseases: above and beyond HIV control.
Nat Rev Neurol. 2016 Feb;12(2):95-105. doi: 10.1038/nrneurol.2015.248. Epub 2016 Jan 18.

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ
Different activation signals induce distinct mast cell degranulation strategies
J Clin Invest. 2016 Oct 3;126(10):3981-3998. doi: 10.1172/JCI85538. Epub 2016 Sep 19.

Mansuy JM, Gallian P, Dimeglio C, Saune K, Arnaud C, Pelletier B, Morel P, Legrand D, Tiberghien P, Izopet J.
A nationwide survey of hepatitis E viral infection in French blood donors.
Hepatology. 2016 Apr;63(4):1145-54. doi: 10.1002/hep.28436. Epub 2016 Feb 26.

Khazen R, Müller S, Gaudenzio N, Espinosa E, Puissegur MP, Valitutti S.
Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse.
Nat Commun. 2016 Mar 4;7:10823. doi: 10.1038/ncomms10823.

Aloulou M, Carr EJ, Gador M, Bignon A, Liblau RS, Fazilleau N and Linterman MA.
Follicular regulatory T-cells can be specific for the immunizing antigen and derive from naive T-cells.

Nat Commun. 2016 Jan 28;7:10579. doi: 10.1038/ncomms10579.

Yshii LM, Gebauer CM, Pignolet B, Mauré E, Quériault C, Pierau M, Saito H, Suzuki N, Brunner-Weinzierl M, Bauer J, Liblau RS
CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model.
Brain. 2016 Sep 6. pii: aww225. [Epub ahead of print]

Ramadan A, Lucca LE, Carrié N, Desbois S, Axisa PP, Hayder M, Bauer J, Liblau RS, Mars LT.
In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS.
Brain. 2016 May;139(Pt 5):1433-46. doi: 10.1093/brain/aww032. Epub 2016 Mar 21.

Bernard-Valnet R, Yshii L, Quériault C, Nguyen XH, Arthaud S, Rodrigues M, Canivet A, Morel AL, Matthys A, Bauer J, Pignolet B, Dauvilliers Y, Peyron C, Liblau RS.
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice.
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10956-61. doi: 10.1073/pnas.1603325113. Epub 2016 Sep 12.

Abravanel F, Métivier S, Chauveau M, Péron JM, Izopet J.
Transmission of HCV NS5A Inhibitor-Resistant Variants Among HIV-Infected Men Who Have Sex With Men.
Clin Infect Dis. 2016 Nov 1;63(9):1271-1272. Epub 2016 Aug 9.

Kassem S, Gaud G, Bernard I, Benamar M, Dejean AS, Liblau R, Fournié GJ, Colacios C, Malissen B, Saoudi A.
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
PLoS Genet. 2016 Jul 20;12(7):e1006185. doi: 10.1371/journal.pgen.1006185. eCollection 2016 Jul.

P. Gravelle , C. Do , C. Franchet , S. Müller, L. Oberic, L. Ysebaert, L. Larocca , S Hohaus, MN Calmels, FX Frenois , R. Kridel , R. Gascoyne, G. Laurent, P. Brousset , *S. Valitutti and *C. Laurent.
Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement.
Oncoimmunology. 2016 Aug 24;5(10):e1224044. eCollection 2016.

Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R.
Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Sci Signal. 2016 May 17;9(428):ra51. doi: 10.1126/scisignal.aad1576.

Cebrian I, Croce C, Guerrero NA, Blanchard N*, Mayorga LS*.(*=co-senior)
Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells.
EMBO Rep. 2016 Dec;17(12):1753-1765. Epub 2016 Oct 10.

Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S.

PPARy Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.
PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016 Apr.




 





Evénements

Séminaires Séminaire le 01/06/2017 à 13h30

présentée par : Dr Nathalie Schmitt

"Human T helper cells in autoimmunity and vaccination"

salle Philippe Druet CPTP, Purpan

Localisation du CPTP

CPTP
INSERM UMR 1043 / CNRS UMR 5282
Université Toulouse III
CHU Purpan
BP 3028
31024 Toulouse CEDEX 03
Tél. : 05 62 74 45 45
Fax : 05 62 74 45 58

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Date de mise à jour 18 mai 2017


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier