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10 déc.

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CPTP Présentation


Directeur : Roland LIBLAU.
Directeurs Adjoints : Paola ROMAGNOLI & Jacques IZOPET

Le Centre de Physiopathologie de Toulouse-Purpan (CPTP) a été l'un des premiers Centres de Recherche biomédicale créés par l'Inserm en 2002... la suite...

Dernières publications


Felix J. Hartmann,Raphaël Bernard-Valnet, Clémence Quériault,Dunja Mrdjen,Lukas M. Weber,Edoardo Galli, Carsten Krieg,Mark D. Robinson, Xuan-Hung Nguyen,Yves Dauvilliers,Roland S. Liblau,Burkhard Becher
High-dimensional single-cell analysis reveals the immune signature of narcolepsy
JEM 2016 Nov (in press)

Cebrian I, Croce C, Guerrero NA, Blanchard N, Mayorga LS.
Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells.
EMBO Reports 2016 (in press)

P. Gravelle , C. Do , C. Franchet , S. Müller, L. Oberic, L. Ysebaert, L. Larocca , S Hohaus, MN Calmels, FX Frenois , R. Kridel , R. Gascoyne, G. Laurent, P. Brousset , *S. Valitutti and *C. Laurent
Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement.
OncoImmunology 2016 (in press)

Pignolet B, Schwab N, Schneider-Hohendorf T, Bucciarelli f, Outteryck O, ongagna JC, De seze J, Brochet B, Ouallet jc, Debouverie M, Pittion S, Defer G, Derache N, Hautecoeur P, Tourbah A, labauge P, Castelnovo G, Clavelou P, berger E, Pelletier J, Rico A, Zephir H, Laplaud D, Wiertlewski S, Camu w, Thouvenot e, casez O, moreau T, fromont A, Vukusic S, papeix c, Biotti D, Averseng-peaureaux D, Vermersch P, Comabella M, Lebrun-frenay C, Wiendl H, Brassat D.
CD62L test at 2 years of Natalizumab predicts progressive multifocal leukoencephalopathy
Neurology 2016 (in press)

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ
Different activation signals induce distinct mast cell degranulation strategies
J Clin Invest. 2016 Oct 3.

El Costa H, Gouilly J, Mansuy JM, Chen Q, Levy C, Cartron G, Veas F, Al-Daccak R, Izopet J, Jabrane-Ferrat N
ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy.
Sci Rep. 2016 Oct 19.

Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick SM, Saoudi A, Dejean AS.
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.
Immunity. 2016 Oct 18.

Mansuy JM, Suberbielle E, Chapuy-Regaud S, Mengelle C, Bujan L, Marchou B, Delobel P, Gonzalez-Dunia D, Malnou CE, Izopet J, Martin-Blondel G.
Zika virus in semen and spermatozoa.
Lancet Infect Dis. 2016 Oct.

Biajoux V, Natt J, Freitas C, Alouche N, Sacquin A, Hemon P, Gaudin F, Fazilleau N, Espéli M, Balabanian K.
Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization.
Cell Rep. 2016 Sep 27.

Bernard-Valnet R, Yshii L, Quériault C, Nguyen XH, Arthaud S, Rodrigues M, Canivet A, Morel AL, Matthys A, Bauer J, Pignolet B, Dauvilliers Y, Peyron C, Liblau RS.
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice.
Proc Natl Acad Sci U S A. 2016 Sep 27.

Yshii LM, Gebauer CM, Pignolet B, Mauré E, Quériault C, Pierau M, Saito H, Suzuki N, Brunner-Weinzierl M, Bauer J, Liblau RS
CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model.
Brain. 2016 Sep 6.

Mansuy JM, Gallian P, Dimeglio C, Saune K, Arnaud C, Pelletier B, Morel P, Legrand D, Tiberghien P, Izopet J.
A nationwide survey of hepatitis E viral infection in French blood donors.
Hepatology. 2016 Apr.

Lucca LE, Axisa PP, Aloulou M, Perals C, Ramadan A, Rufas P, Kyewski B, Derbinski J, Fazilleau N, Mars LT, Liblau RS.
Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self-antigen in mice.
Eur J Immunol. 2016 Sep.

Kassem S, Gaud G, Bernard I, Benamar M, Dejean AS, Liblau R, Fournié GJ, Colacios C, Malissen B, Saoudi A.
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
PLoS Genet. 2016 Jul 20.

Khazen R, Müller S, Gaudenzio N, Espinosa E, Puissegur MP, Valitutti S.
Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse.
Nat Commun. 2016 Mar 4.

Ramadan A, Lucca LE, Carrié N, Desbois S, Axisa PP, Hayder M, Bauer J, Liblau RS, Mars LT.
In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS.
Brain. 2016 May.

Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R.
Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Sci Signal. 2016 May 17.

Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S.
PPARy Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.
PLoS Pathog. 2016 Apr 14.

Ferré CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M.
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential.
FASEB J. 2016 Apr.

Mansuy JM, Dutertre M, Mengelle C, Fourcade C, Marchou B, Delobel P, Izopet J, Martin-Blondel G.
Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?
Lancet Infect Dis. 2016 Apr.

Aloulou M, Carr EJ, Gador M, Bignon A, Liblau RS, Fazilleau N and Linterman MA.
Follicular regulatory T-cells can be specific for the immunizing antigen and derive from naive T-cells.

Nat Commun. 2016 Jan 28;7:10579. doi: 10.1038/ncomms10579.

Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS.
CCR5 blockade for neuro-inflammatory diseases: above and beyond HIV control.
Nat Rev Neurol. 2016 Feb.

Joncker NT, Bettini S, Boulet D, Guiraud M, Guerder S.
The site of tumor development determines immunogenicity via temporal mobilization of antigen laden dendritic cells in draining lymph nodes.
Eur J Immunol. 2015 Dec 2. doi: 10.1002/eji.201545797.

Ferré CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M.
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential.
FASEB J. 2015 Dec 23. pii: fj.15-279620.

Decque A, Joffre O, Magalhaes JG, Cossec JC, Blecher-Gonen R, Lapaquette P, Silvin A, Manel N, Joubert PE, Seeler JS, Albert ML, Amit I, Amigorena S, Dejean A.
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.
Nat Immunol. 2015 Dec 14. doi: 10.1038/ni.3342.

Siewiera J, Gouilly J, Hocine HR, Cartron G, Levy C, Al-Daccak R, Jabrane-Ferrat N.
Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes.
Nat Commun. 2015 Dec 15;6:10183. doi: 10.1038/ncomms10183.

Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N
Intravacuolar membranes regulate CD8 T cell recognition of membrane-bound Toxoplasma gondii protective antigen.
Cell Rep 2015 Nov 23. pii: S2211-1247(15)01288-7. doi: 10.1016/j.celrep.2015.11.001.

Viret C, Mahiddine K, Baker RL, Haskins K, Guerder S.
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.
J Immunol. 2015 Sep 1;195(5):1964-73. doi: 10.4049/jimmunol.1401683. Epub 2015 Jul 24.

Caminade AM, Fruchon S, Turrin CO, Poupot M, Ouali A, Maraval A, Garzoni M, Maly M, Furer V, Kovalenko V, Majoral JP, Pavan GM, Poupot R.
The key role of the scaffold on the efficiency of dendrimer nanodrugs.
Nat Commun. 2015 Jul 14;6

Vasconcelos Z, Müller S, Guipouy D, Yu W, Christophe C, Gadat S, Valitutti S, Dupré L.
Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing.
Cell Rep. 2015 Jun 9;11(9):1474-85. doi: 10.1016/j.celrep.2015.05.002. Epub 2015 May 28.

Thiault N, Darrigues J, Adoue V, Gros M, Binet B, Perals C, Leobon B, Fazilleau N, Joffre OP, Robey EA, van Meerwijk JP, Romagnoli P.
Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.
Nat Immunol. 2015 May 4. doi: 10.1038/ni.3150.

Liblau RS, Vassalli A, Seifinejad A, Tafti M
Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy
Lancet Neurol. 2015 Mar;14(3):318-28. doi: 10.1016/S1474-4422(14)70218-2.

Waisman A, Liblau RS, Becher B
Innate and adaptive immune responses in the CNS
Lancet Neurol 2015; 14: 945–55

Malet-Engra G, Yu W, Oldani A, Rey-Barroso J, Gov NS, Scita G, Dupré L.
Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.
Curr Biol. 2015 Jan 19;25(2):242-50. doi: 10.1016/j.cub.2014.11.030.

Iriart X, Challan Belval T, Fillaux J, Esposito L, Lavergne RA, Cardeau-Desangles I, Roques O, Del Bello A, Cointault O, Lavayssière L, Chauvin P, Menard S, Magnaval JF, Cassaing S, Rostaing L, Kamar N, Berry A.
Risk factors of Pneumocystis pneumonia in solid organ recipients in the era of the common use of posttransplantation prophylaxis.
Am J Transplant. 2015 Jan;15(1):190-9. doi: 10.1111/ajt.12947.

Joulia R, Gaudenzio N, Rodrigues M, Lopez J, Blanchard N, Valitutti S, Espinosa E.
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.
Nat Commun.
2015 Jan 28;6:6174. doi: 10.1038/ncomms7174.

Abravanel F, Lhomme S, Rostaing L, Kamar N, Izopet J.
Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse.
Clin Infect Dis.
2015 Jan 1;60(1):96-9. doi: 10.1093/cid/ciu742.

 





Evénements

Séminaires Séminaire le 14/12/2016 à 13h30

présentée par : Cyril Seillet

Deciphering The Innate Lymphoid Cell Transcriptional Program

Salle P. Druet, CPTP Bât A rdc, CHU Purpan

Localisation du CPTP

CPTP
INSERM UMR 1043 / CNRS UMR 5282
Université Toulouse III
CHU Purpan
BP 3028
31024 Toulouse CEDEX 03
Tél. : 05 62 74 45 45
Fax : 05 62 74 45 58

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Date de mise à jour 10 novembre 2016


Centre de physiopathologie de Toulouse Purpan - CHU Purpan - BP 3028 31024 Toulouse Cedex 3
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier